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Articles

The use of nuclear magnetic resonance as an analytical tool in the characterisation of dispersion behaviour

David Fairhurst, Stuart Prescott

Nuclear magnetic resonance (NMR) spectroscopy is one of the most powerful analytical tools used to probe details of molecular structure and dynamics. It requires very high magnetic fields and, hence, generally uses extremely large, powerful magnets. The advent of small, powerful magnets has allowed much less expensive low resolution NMR instrumentation to be designed, making it feasible to measure commercially important characteristics of dispersion behaviour and performance, including the wetted surface area of particulate suspensions and emulsion droplet size. An important additional practical application is the ability to determine competitive adsorption and/or displacement of polymers and surfactants at interfaces. This article presents a brief overview of these new approaches together with an example of each measurement.

Article  |  Issue 23/4 (2011)

A new approach to improving automated analysis of proton NMR spectra through Global Spectral Deconvolution (GSD)

Carlos Cobas, Felipe Seoane, Santiago Domínguez, Stan Sykora, Antony N. Davie

1H NMR spectra are usually interpreted by hand, which is very time consuming, and can become a process bottleneck in fields such as high-throughput NMR. Greater automation of the spectral analysis process has become essential if NMR is to be of value as a high-throughput analytical method in the future.

Tony Davies Column  |  Issue 23/1 (2011)

Rapid NMR screening of total aldehydes to detect oxidative rancidity in vegetable oils and decorative cosmetics

Dirk W. Lachenmeier, Marina Gary, Yulia B. Monakhova, Thomas Kuballa, Gerd Mildau

Dirk Lachenmeier, Marina Gary, Yulia Monakhova, Thomas Kuballa and Gerd Mildau describe “Rapid NMR screening of total aldehydes to detect oxidative rancidity in vegetable oils and decorative cosmetics”. Lipid oxidation produces rancid products, which are both unpleasant and potentially toxic. The authors describe the use of NMR to screen food and cosmetic products. Whilst, vegetable oils were generally found to be in good condition, German women may wish to be careful of their lipstick, especially if they have had kept it for a while!

Article  |  Issue 22/6 (2010)

A toast to dynamic NMR spectroscopy: towards a better comprehension of palatable emulsions

David Carteau, Isabelle Pianet , Dario M. Bassani

An NMR tour of Mediterranean anise-flavoured alcoholic beverages.

Article  |  Issue 21/5 (2009)

DOSY NMR, a new tool for fake drug analyses

Stéphane Balayssac, Véronique Gilard, Marc-André Delsuc, Myriam Malet-Martino

This article outlines the use of the DOSY NMR method applied to drug analysis and screening for counterfeit drugs or fake herbal medicines

Article  |  Issue 21/3 (2009)

A short history of magnetic resonance imaging

Peter A. Rinck

A brief history and personal recollection of the development of magnetic resonance imaging (MRI).

Article  |  Issue 20/1 (2008)

Who has the best proton NMR crystal ball?

A.N. Davies

There has been much debate about which program can predict NMR spectra the best. It is well known within the NMR community that spectra prediction strongly depends on the “quality” of the starting data sets for those systems which use real data as a knowledge base. It has become a hot topic in some blogs, although disappointingly most of the authors tend to have affiliations to one software vendor or another.

Tony Davies Column  |  Issue 20/1 (2008)

Quantitative NMR spectroscopy in the quality evaluation of active pharmaceutical ingredients and excipients

Bernd W.K. Diehl, Frank Malz, Ulrike Holzgrabe

The purpose of this short review article is to highlight some capabilities of qNMR spectroscopic methods in drug quality evaluation, indicating that qNMR spectroscopy should be more often applied when chromatographic methods are not working effectively.

Article  |  Issue 19/5 (2007)

Nuclear magnetic resonance: stepping up to the PAT challenge

Michael A. Bernstein

Our focus here is analytical procedures and the role of nuclear magnetic resonance (NMR) in particular. These have, until now, largely relied on conventional chromatography, and vibrational spectroscopy—infrared (IR), Raman and near infrared (NIR) spectroscopy. In spite of inherent difficulties with peak assignment and reliable quantification, vibrational spectroscopy has been used to derive information on reaction progression to impart fundamental understanding. This article sets out a wider scope to show how NMR can play a key role. Furthermore, NMR integrates well with established procedures to provide a suite of useful technologies that make the PAT challenge tractable.

Article  |  Issue 19/4 (2007)

The power of electron paramagnetic resonance spectroscopy in pharmaceutical analysis

Helen Williams and Mike Claybourn

AstraZeneca, Silk Road Business Park, Macclesfield, Cheshire, SK10 2NA, UK

Article  |  Issue / ()

The prediction of 1H NMR chemical shifts in organic compounds

Raymond J. Abraham and Mehdi Mobli

Chemistry Department, The University of Liverpool, PO Box 147, Liverpool L69 3BX, UK

Article  |  Issue / ()

Highlight Article: LC-NMR/MS

Steve Down

HD Science Limited, 16 Petworth Avenue, Toton, Nottingham NG9 6JF, UK

Article  |  Issue / ()

Olive oil as seen by NMR and chemometrics

Luisa Mannina, Anatoli P. Sobolev, Annalaura Segre

Luisa Mannina,a,b Anatoli P. Sobolevb and Annalaura Segreb

aUniversity of Molise, Faculty of Agriculture, 86100 Campobasso, Italy
bInstitute of Chemical Methodologies, CNR, 00016 Monterotondo Staz., Rome, Italy

Article  |  Issue 15/3 (2003)

Superconducting magnets: at the heart of NMR

Alan Street

Technical Director, Oxford Instruments Superconductivity

Article  |  Issue / ()

NMR: still listening to whispering hydrogens? What else do they tell us 50 years after their discovery?

Marion Menzel, Bernhard Blümich

It is now more than fifty years ago that Felix Bloch and Edward Mills Purcell independently discovered a phenomenon called nuclear magnetic resonance (NMR). Only a few years later, in 1952, both received the Nobel Laureate Physics award for this discovery. Purcell and Bloch were the first to “listen” to the whisperings of hydrogen. They eventually obtained an NMR spectrum representing the different “pitches” of the nuclei, a property, which reflects the physico–chemical (electronic) neighbourhood of the nucleus.

Article  |  Issue 14/4 (2002)

900 MHz nuclear magnetic resonance shows great promise

Ēriks Kupïe, Steve Smallcombe

A stage in the ever-increasing magnetic field strengths in NMR spectroscopy.

Article  |  Issue 13/1 (2001)

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