Spectroscopy Since 1975
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Articles

Four Generations of Quality timeline
John P. Hammond

John Hammond finishes his magnum opus on “Four Generations of Quality” with a look at what is science fiction and what is science fact. He considers what may turn out to be “fact” in the future for each of the preceding eight articles in the series.

QM Column  |  Issue 34/6 (2022)
Photo of quantum dots in tubes
John P. Hammond

This article looks at three related spectroscopic techniques/tools in the toolbox, namely, Fluorescence, near infrared (NIR) and Raman; and discuss the “what”, “where” and “how” of these techniques are being used to improve the quality of the measurement processes associated with them.

QM Column  |  Issue 34/4 (2022)
Dmitry Gakamsky, Anna Gakamsky

Dmitry Gakamsky and Anna Gakamsky describe how fluorescence may be used to diagnose cataracts in human eye lenses. Further, it may also be able to grade cataracts and monitor the disease’s progress, which may help discover metabolic and ambient factors that influence the progress of the disease.

Article  |  Issue 29/3 (2017)
Martin Byrdin, Dominique Bourgeois

The CAL(AI)2DOSCOPE (Cryogenic Absorption/Luminescence Alignment Independent Alternative Intermittent Detection Optical µSCOPE) is a microspectrometer that was constructed with the aim to facilitate the correlated investigation of absorption and fluorescence emission properties of nanovolumic protein samples under modulatable actinic illumination.

Article  |  Issue 28/6 (2016)
Ewa Sikorska, Igor Khmelinskii

Whilst the major components of food are usually non-fluorescent, many minor food components that affect its nutritive, compositional and technological quality are fluorescent. Given its sensitivity, ease of use and non-destructive nature, this makes it useful in many applications around monitoring food processing and in fundamental food research.

Article  |  Issue 28/6 (2016)
Arja M. Kullaa, Surya P. Singh, Jopi W. Mikkonen, Arto P. Koistinen

“Optical spectroscopy in therapy response monitoring: an awakening giant” by Arja Kullaa, Surya Singh, Jopi Mikkonen and Arto Koistinen looks at the important advances made by optical spectroscopy techniques, such as diffuse optical spectroscopic imaging (DOSI), Raman, diffuse reflectance and fluorescence spectroscopy, in changing how cancer is managed in patients. The ability to repeatedly monitor tumour dynamics to see how effective a particular treatment has been has enormous potential for us all.

Article  |  Issue 27/1 (2015)
Patrick Garidel, Anne R. Karow, Michaela Blech

Orthogonal spectroscopic techniques for the early developability assessment of therapeutic protein candidates” are described by Patrick Garidel, Anne Karow and Michaela Blech. Due to its cost and time implications, in the early development phase of drug discovery the use of  othogonal techniques, based on different physical observables, is important for correct decision-making.

Article  |  Issue 26/4 (2016)
Patrick Garidel

In the pharmaceutical industry, biologicals are of increasing interest due to their high therapeutic benefits. Amongst many other questions, the stability of new canditates is of great importance. Patrick Garidel describes this in “Right angle light scattering protein thermostability screening: from research to development”. The ability of this and other fluorescence-based techniques to detect very small quantities is of great benefit.

Article  |  Issue 24/1 (2012)
Jean-Philippe Echard, Loïc Bertrand

Jean-Philippe Echarda and Loïc Bertrandb

aLaboratoire de recherche et de restauration, Musée de la musique, Cité de la musique, 221 avenue Jean Jaurès, 75019 Paris, France. E-mail: [email protected]
bIPANEMA, synchrotron SOLEIL, Saint-Aubin, 91192 Gif-sur-Yvette cedex, France

Article  |  Issue 22/2 (2010)
Patrick Garidel

Patrick Garidel

Boehringer Ingelheim Pharma GmbH & Co. KG, Process Science, Pharmaceutical Basic Development, D-88397 Biberach an der Riss, Germany. E-mail: [email protected]

Article  |  Issue 20/4 (2008)

Jens Petter Wold

MATFORSK, Norwegian Food Research Institute, Osloveien 1, 1430 Ås, Norway

Article  |  Issue / ()
Mikael Kubista, Jahan Ghasemi, Björn Sjögreen, Amin Forootan

Mikael Kubista, Jahan Ghasemi, Björn Sjögreen and Amin Forootan

MultiD Analyses AB, Göteborg, Sweden. E-mail: [email protected]

Article  |  Issue 16/6 (2004)