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ICP-MS to count and identify viruses

28 April 2021 | News
by Ian Michael

A new methodology, which has been adapted from the use of ICP-MS to identify metallic nanoparticles, is able to detect the presence of viruses within just 20 s. The proposed technique, called “Single virus inductively coupled plasma mass spectroscopy” (SV ICP-MS), can be used to quickly determine families of viruses. However, although the concept can identify that someone has a type of coronavirus, for example, it would not be able to determine the type of coronavirus, or variants. Additional tests would still be required to find out the specific virus someone was infected with.

The idea, developed by Professor Claude Degueldre, from Lancaster University’s Department of Engineering, uses diluted samples of fluids, such as nasal mucus or saliva, from patients. Measurements of intensities for selected masses of the elements from the viruses provide rapid results to show the presence of a virus or not. This process works on DNA and RNA virus types within seconds. Another key benefit is the ability to test a large number of samples quickly.

Professor Degueldre said: “What we are proposing here is not a new Covid test but is a new concept to rapidly find out if there are viruses present. This would be useful if people are ill but it is not known if they have a virus or another health condition that is making them sick. This concept would inform the clinical team whether or not there is a virus to inform early treatment actions and other measures such as the need for isolation. More detailed tests would still be required to discover the exact viral infection, but results from these take longer. Another application for the concept is to test water samples from sewage systems or down flow in rivers. The results would enable public health experts to identify areas of cities that have viral outbreaks.”

The concept is still at an early stage and further research and experiments are needed to further develop the process.

Read the original journal paper in Talanta

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