The pharma industry is moving towards large molecule biologicals, which are much more complex and require more spohisticated analytical tools. Waters has introduced the BioAccord™ System that can be operated by almost anyone in the lab. BioAccord is a liquid chromatography-mass spectrometry (LC-MS) instrument that uses the ACQUITY UPLC™ I-Class Plus with the ACQUITY RDa™ Detector; a small footprint time-of-flight mass spectrometer specifically developed for the BioAccord. Dedicated workflows for intact protein mass, released glycans and peptides have been developed for the system. System integration and application test is performed at the Waters factory, so the system is ready to go on installation. There are automated setup and self-diagnosis routines, and the BioAccord runs under UNIFI™, Waters’ compliance-ready LC-MS informatics platform.