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LC-MS discovers Viagra and other hidden ingredients in dietary supplements

8 August 2015 | News

There is a wide variety of dietary supplements available to the general public, but some of these products contain undeclared substances. Writing in the Journal of Agricultural & Food Chemistry, a group of scientists from China have developed a liquid chromatography-mass spectrometry screening procedure to protect consumers from taking something without their knowledge. Their approach has enabled them to find the active Viagra ingredient and other synthetic designer compounds in various products.

Dietary supplements can appear to be a healthy option for treating certain conditions. Their labels list herbs or other natural ingredients that consumers assume are safe to take. But over the past several years, regulators have detected prohibited substances in some of these products that are not included on the labels. The drug sibutramine is one of these substances. It was once approved for weight loss but was withdrawn after concerns arose that the medication could increase the risk of heart attacks. To catch supplements spiked with sibutramine and other undeclared substances, Zhiqiang Huang, Bin Guo and colleagues came up with a strategy. Using an advanced LC-MS screening procedure, the researchers tested more than 100 syrups, capsules and other types of supplements purchased in markets in China and online. The products’ labels claimed benefits from blood pressure reduction to enhanced sexual performance. Their approach successfully detected a wide range of targeted adulterants—including sibutramine and sildenafil, the active ingredient in Viagra—and other unexpected drug compounds.

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