Thermo Fisher Scientific has introduced a differential ion mobility device that integrates with high-resolution mass spectrometers. The Thermo Scientific FAIMS Pro interface is designed to increase the range of proteins scientists can identify while reducing the time taken in sample preparation steps. Its new design further enhances instrument selectivity and detection limits through gas-phase fractionation and reduced matrix interference. Menu-driven software can be used to design methods using pre-configured parameters, increasing productivity and simplifying use. Sample fractionation steps are reduced, which can help save time, long-term costs and maintenance through increased productivity. The FAIMS Pro device’s interface has been designed to improve nano, capillary and microflow applications, producing high data quality on sample-limited studies.