Thermo Scientific have added enhancements to their Orbitrap Fusion Lumos Tribrid mass spectrometer that extend its power, performance and versatility. The Integrated Ultraviolet Photodissociation (UVPD) allows researchers to perform large and small molecule structure determination on an LC time scale. Now an optional feature on Orbitrap Fusion Lumos systems, this fragmentation mode is designed to improve sequence coverage and antibody characterisation, decrease scrambling in top-down hydrogen deuterium exchange (HDX) experiments and to be a complete solution for structural characterisation of lipids and other metabolites. A new Advanced Peak Determination (APD) algorithm is designed to improve the performance of most proteomic workflows with high peptide and protein identification rates in data-dependent experiments. 1M resolution is also a new option, used to obtain unique structural and quantitative information for a wide range of compound classes.