908 Devices announced several advancements to their ZipChip® product line. Two consumable enhancements dubbed BOOST and SHIFT improve sensitivity and enable native protein analysis on a broader range of Thermo Fisher Scientific mass spectrometers. BOOST gives researchers 20× greater sensitivity when performing native intact protein analysis, revealing detail that was previously unresolvable. SHIFT brings native analysis to mass spectrometers with limited high-mass sensitivity. This now allows biopharmaceutical scientists to run native capillary electrophoresis-mass spectrometry assays on their existing, non-extended-mass range instrumentation without a hardware upgrade.
The company also announced compatibility of their ZipChip platform with a wider range of high-resolution accurate mass instrument manufacturers. Compatibility now expands to a broader set of SCIEX mass spectrometers to include SCIEX TOF instruments in addition to Triple Quad and QTRAP® series systems. 908 Devices and Bruker have also entered into a collaboration agreement to integrate ZipChip onto Bruker mass spectrometers. This collaboration is specifically aligned to bring fast and simple ZipChip CE separations to the Bruker line of TOF instruments including the timsTOF Pro and MaXis systems for the characterisation of Critical Quality Attributes in the biotherapeutics area.