VUV Analytics has announced the launch of a new method for residual solvent testing in pharmaceutical products and excipients that reduces analysis time while allowing the combination of different sample types into a single test. The gas chromatography-vacuum ultraviolet (GC-VUV) spectroscopy method reduces the GC separation time recommended by the Unites States Pharmacopeia (USP) Method 467 of 60 min to 8 min or less. In addition, residual solvent classes typically run as separate tests can be combined into a single GC run due to VUV spectroscopy’s ability to provide unambiguous compound identification and quantitation even when signals overlap.
Organic solvents are used in the synthesis of active pharmaceutical ingredients (APIs) and can contaminate drugs during packaging, storage and transportation. They account for 50–90% of the mass in typical pharmaceutical operation and present most of the process toxicity. This new GC-VUV method ensures complete identification of any solvents remaining from synthesis while delivering faster time to results.