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Tag: Mass spectrometry Ordering

A high-throughput direct ionisation system for profiling the distribution of biomolecules. The “smart-source” offers access to and visualisation of molecules of interest directly where they exist. The system conveniently integrates with different mass spectrometers, including single quad, triple quad, ToF and HDMS systems from several manufacturers. Fully adjustable vertical and horizontal articulation enable the system to fit various bench heights and mass spectrometry set-ups.

Similar to the Series 200, but with a larger mass range of 5–2150 m/z, and suitable for laboratories performing routine assays. Again, available in single source and dual source versions. The Torrent Multi-Option Dual Source can be configured for ESI/ESI, ESI/APCI or APCI/APCI. Patented interfaces are available: the HSID on the Series 100 and HSID Select on the Series 200; HSID stands for Hot Source-Induced Desolvation. There is also a zero cross-talk collision cell and patented “Unifield” detector.

Second generation of their triple quadrupole mass spectrometer series. The 3Q 220 has a dual source and the 3Q 210 a single source. The Series 200 instruments are designed for high sensitivity, e.g. quantitation of free testosterone at 1.2 pg mL–1 or fentanyl to 250 ag mL–1.

NIST 11 standard reference MS library searching has now been integrated with this PC-based application software. The software now provides a seamless interface for passing an unidentified compound’s mass spectra to be searched against the mass spectral library, including Retention Index data.

Tony (A.N.) Davies is after your advice in his latest column “Your committee needs you!”. The IUPAC Subcommittee on Electronic Data Standards is keen to learn about areas where you would like to see improvements in moving your data between your analytical instruments and data analysis and reporting packages.

Archaeologists examining late period Mayan containers have identified nicotine traces from a codex-style flask, revealing the first physical evidence of tobacco use by ancient Mayans. The study published in Rapid Communications in Mass Spectrometry reveals the flask is marked with Mayan hieroglyphics reading, “y-otoot ’u-may” (“the home of its/his/her tobacco”), making it only the second case to confirm that the text on the exterior of a Mayan vessel corresponds to its ancient use.

Monitoring drinking water quality poses many challenges and the authors describe their approach that combines instrumental developments with new software.

Due to the importance of imaging mass spectrometry in the life sciences, the Joint Committee of the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) has decided, as part of the “Imaging Mass Spectrometry in the Life Sciences” initiative, to equip nine universities with major instrumentation systems.

Tony (A.N.) Davies is impressed with the service form the UK's EPSRC National Mass Spectrometry Service Centre.

Chemical contaminants in water are of concern to all of us. This article reviews the use of mass spectrometry (MS) in environmental and wastewater analysis.

After an introduction to MALDI, DESI and SIMS, the authors describe their main applications in forensics, as well as the advantages provided in terms of sample preparation over approaches routinely used in toxicological laboratories.

The HPR series of mass spectrometer-based gas analysers from Hiden Analytical has been expanded further to include analysis of static off-line gas samples in addition to the more routine conditions of dynamic flow. New additions include the HPR-70 bench-top system for gas composition measurement of small individual discreet samples with the gas preparation stage including selectable cascade volumes for pressure optimisation over a wide spread of sample volumes and sample pressures. Samples will normally be acquired and contained off-line as the container has an isolation valve or break-seal for direct connection to the mass spectrometer. The HPR-90 system uses similar mass spectrometer stages together with a customised inlet system specifically configured for analysis of gases trapped within enclosed volumes. It is totally enclosed within a UHV-compatible evacuated vacuum vessel and is equipped with appropriate cracking or drilling facilities to enable release of the gas sample for immediate analysis. Package volumes from 10 litres down to sub-millilitres are accommodated. The systems offer a choice of manual or automated operation and include multiple calibration routines for data quantification, enabling measurement of low-level gas components to the sub-ppm level.

Waters has introduced an addition to its vials product line. The TruView LC/MS certified vials include the stringent dimensional tolerances, UV and MS cleanliness tests required for the company's LC/GC and LC/MS certified vial lines. An additional feature of TruView vials is that the glass surface exhibits low polar analyte adsorption. The vials are manufactured under tightly controlled process conditions that limit the concentration of free ions on the surface of glass. Low levels of free ions on the surface of glass result in low analyte adsorption. Applications involving sensitive MS/MS spectrometers operate at analyte concentrations of ng mL–1 to pg mL–1 levels. At these concentrations, analyte adsorption can compromise analytical results. The TruView certified vials are tested for high recovery of analyte at 1 ng mL–1 concentration using UPLC/MS/MS (MRM) and yield little adsorption.

Researchers have used mass spectrometry imaging to uncover exactly how a human egg captures an incoming sperm to begin the fertilisation process, in a new study published this week in Science. The research identifies the sugar molecule that makes the outer coat of the egg “sticky”, which is vital for enabling the sperm and egg to bind together. Researchers across the world have been trying to understand what performs this task for over 30 years.

This Product Focus is on Mass Spectrometry, and a number of companies have provided information on their key products, their applications and features.

Applications of mass spectrometry in the clinical area have increased significantly in recent years and continue to expand. The complexity of analyses has also increased, with work being undertaken in clinical labs that would have been the reserve of research labs a few years ago.

The European Molecular Biology Organization (EMBO) and the Federation of European Biochemical Societies (FEBS) announce Carol V. Robinson, Professor of Chemistry at the University of Oxford, UK, as the winner of the 2011 FEBS/EMBO Women in Science Award. Professor Robinson has been recognised for her pioneering work in the development of mass spectrometry as a tool used for investigating the structure and dynamics of protein complexes.