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Free Waters Corporation Webinar:Dried Blood Spot Bioanalysis: Addressing the Sensitivity Challenge
Dried blood spots (DBS) have been used for many years in neonatal testing using either a heel or finger prick onto a piece of paper which is then dried and shipped for analysis. This approach has now been applied to the field of bioanalysis in preclinical, toxicokinetic, and clinical studies. DBS has several benefits.
Friday, September 3, 2010
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Counterfeiting of drugs is a huge industry with an annual turnover of more than €50 billion. In Africa the situation is extremely serious: half of the malaria medication sold there could be ineffective or even harmful. Researchers from Lund University, Sweden, and King’s College London, UK, have now developed a technique based on nuclear magnetic resonance (NMR) that could provide a good way to identify counterfeit drugs.
Read more: Problem of fake medicines in developing countries could be solved by NMR
Infrared spectroscopy can detect E. coli faster than current testing methods and can cut days off investigations of outbreaks, according to a study at Purdue University, West Lafayette, IN, USA.
Magnetic Resonance Spectroscopy can distinguish between neurological diseases in patients without clear symptoms.
Read more: Research Heralds Potential for Early Diagnosis of Degenerative Brain Disorders
Water molecules are continuously forming short-lived networks called clusters. These can in turn bind positively charged protons, and such clusters can provide active functional groups in proteins. Using infrared spectroscopy, it is possible to determine the bond strengths, geometrical structures and chemical properties of protonated water clusters. In order to measure the spectrum of molecular vibrations in clusters it is, however, necessary to use other molecules as messengers. A team of physicists and chemists including Dr Gerald Mathias of Ludwig-Maximilians-Universität (LMU) in Munich and Professor Dominik Marx of the Ruhr-Universität Bochum has, for the first time, described how these messengers influence the assignment of spectral bands by infrared spectroscopy.
Read more: Mapping the Structure of Protonated Water Clusters
Scientists at the Georgia Institute of Technology, GA, USA, have attained very promising results on their initial investigations of a new test for ovarian cancer. Using a new technique involving mass spectrometry of a single drop of blood serum, the test correctly identified women with ovarian cancer in 100% of the patients tested.
Read more: Initial Trials on New Ovarian Cancer Tests with Mass Spec Exhibit Extremely High Accuracy
Bruker Corporation has signed an agreement to acquire the Scanning Probe Microscopy (SPM) and Optical Industrial Metrology (OIM) instruments business from Veeco Instruments, Inc. for $229 million in cash. The transaction has been approved by the Boards of Directors of both companies and is expected to close during the fourth quarter of 2010, pending regulatory review and subject to customary closing conditions.
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