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Bruker and several collaborating scientists are presenting a number of milestone achievements in the analysis of intact proteins, including the direct sequencing and characterisation using Bruker's new maXis ETD system. The high mass accuracy, resolving power and dynamic range which are essential to dissect complex patterns of product ions in protein fragmentation allowed, for the first time, performing ETD-based tandem mass spectrometry on biomolecular ions above 60 kDa routinely. These results represent a new record for the mass spectrometric sequencing of intact proteins and unequivocally demonstrate the dramatic advantages of maXis ETD technology in ETD-based top-down protein structural analysis.
Bruker Introduces MS Workstation 7 Software for New Chemical Analysis Gas Chromatography Triple-Quadrupole Mass Spectrometers
Bruker Daltonics' new Chemical Analysis business announced the release of MS Workstation 7, the next generation software package for the newly acquired 3x0 series GC triple-quadrupole (GC-QQQ) mass spectrometers. MS Workstation 7 features Scheduled Multiple-Reaction Monitoring (s-MRM), which facilitates method development, maintenance and data reduction tasks for challenging multi-component methods.
JEOL USA have introduced of the company’s first commercially available MALDI-ToF mass spectrometer, the JEOL JMS-S3000 SpiralTOF. The SpiralTOF has new ToF ion optics with an extended flight length in a compact footprint, delivering a resolving power of greater than 60,000 (FWHM) over a wide mass range of m/z 10–30,000.
PerkinElmer is launching the Flexar SQ 300 MS platform at ASMS. Combining efficient chromatographic separation with mass spectrometry detection capabilities, the new Flexar SQ 300 MS system is designed for analysts seeking a fast, accurate and robust system to quickly identify and quantify compounds.
PerkinElmer and Abbott to Present on Time-of-Flight Mass Spectrometry for Pathogen Detection Research
PerkinElmer and Abbott have announced that the companies will jointly present on the applications of exact mass time-of-flight (ToF) mass spectrometry for advancing pathogen detection research at ASMS.
Shimadzu and bioMerieux have entered into a partnership to commercialise a mass spectrometry system for bacterial identification in microbiology laboratories. bioMerieux will work with Shimadzu and their subsidiary, Kratos Analytical, to adapt their linear MALDI-ToF mass spectrometry technology for optimised integration into the microbiology laboratory workflow. This new solution is planned for commercialisation by bioMerieux in 2010, together with the microbial database acquired from AnagnosTec.
A new study from the Swedish medical university Karolinska Institutet presents a technique using LC-MS/MS that makes drug testing possible through exhaled air for the first time. By examining people who had received emergency care for an amphetamine overdose, the researchers found that in all cases there were traces of amphetamine and metamphetamine in the exhaled breath.
Coupling an isotope ratio mass spectrometer to an elemental analyser or gas chromatograph/combustion system has been used to analyse squalene and squalane, oils often used in the production of cosmetics and vaccines, and can show whether they came originally from the liver oil of deepwater sharks or from olive oil.
Lipids produced by the aspirin target COX-2 have anti-oxidant and anti-inflammatory properties as presented in a study published online this week in Nature Chemical Biology (doi: 10.1038/nchembio.367).
New Webinar from Bruker Daltonics
High Sensitivity ICP-MS:Overcome the challenge of complex samples
The new aurora M90 from Bruker defines new performance standards in ICP-MS combined with ease of use and robustness required in today’s modern laboratories.
The patented ingenious ion optic design combined with the innovative collision / reaction interface cell delivers highest selectivity and class leading sensitivity, which supersedes all other quadrupole ICP-MSs offered on the market and matches even sensitivity standards set by sector field ICP-MS, all combined with ease of use, robustness, low-cost of ownership and low instrument investment need.
The webinar will explain the technical realization of the instrumentation and demonstrate the benefits for the most challenging applications in ICP-MS analysis.
Who should attend?ICP-MS users Lab managers Students ….
Your PresentersDr. Meike Hamester, Director European ICP-MS Marketing, Bruker Daltonics, Berlin, GermanyMeike Hamester’s passion for ICP-MS started in the early ’90s at the University of Hamburg, Germany. During her thesis with the title ‘Minimization of spectral and non-spectral interferences using ICP-MS’ she got acquainted with the challenges of ICP-MS in the early stages. Having finished her thesis she moved from Hamburg to Bremen in Germany to work for Finnigan and its successor Thermo Fisher Scientific as the product manager for ICP-MS. In January 2012 Meike joined Bruker Daltonics as European director for ICP-MS. Meike is based at Bruker in Berlin, Germany where Bruker operates the Application Laboratory for ICP-MS. Andrew Toms, ICP-MS Specialist, Bruker Daltonics, Milton, CanadaAndrew Toms has been involved with ICP-MS since his undergraduate studies at Memorial University of Newfoundland. After completing his Masters degree at University of Windsor where he studied mercury contamination in lake sediments, Andrew joined Varian Canada as a technical support chemist in 2000, in Mississauga, Ontario. Following 10 years with Varian in applications support and customer training, he joined Bruker Daltonics as an ICP-MS Specialist in May 2010, based out of their applications laboratory at their Milton location, near Toronto.
Thermo Fisher Scientific has acquired Proxeon A/S, an innovative supplier of products for proteomics analysis based in Odense, Denmark. The company provides a simplified proteomics workflow, including nanoflow liquid chromatography systems, columns, ion sources and bioinformatics software, to meet the need for robust high-sensitivity liquid chromatography/mass spectrometry (LC/MS) analysis in complex proteomics applications. Proxeon had revenues of approximately $10 million in 2009 and has nearly 40 employees.
Scientists at Barts and The London School of Medicine and Dentistry at Queen Mary University of London, have developed a novel mass spectrometry-method of analysing and interpreting cell signalling pathways. This technology enables the pharmaceutical and biotechnology industry to identify biomarkers and better select new drugs for diseases such as cancer, autoimmunity and diabetes and help reduce their time to market.
Matthew Collins,a Mike Buckley,a Helen H. Grundy,b Jane Thomas-Oates,a Julie Wilsona and Nienke van DoornaaBioArCh, Departments of Biology, Archaeology and Chemistry, the University of York, York YO10 5DD, UKbThe DEFRA Food and Environmental Research Agency (FERA), Sand Hutton, York YO41 1LZ, UK
This year the International Barcode of Life initiative (IBoL) plans to begin an ambitious programme to barcode the DNA of more than five million specimens representing at least 500,000 species in five years. Molecular barcodes exploit the fact that molecular sequences offer an independent method to identify a sample. Such molecular barcodes have widespread application in systematics, biodiversity, forensics and even food science. Molecular barcodes tend to be based upon DNA, which with the advent of new technologies offers a fast and efficient means of identification. Proteins too have been used in the past for molecular identification, most commonly exploiting the exquisite specificity of antibodies to discriminate targeted proteins. Recently the idea of using protein mass spectrometry to fingerprint samples has been used to target samples in which processing or decay has destroyed the DNA.
Bruker Corporation has created a Chemical Analysis Division within its Bruker Daltonics subsidiary. The new Chemical Analysis Division will be managed by Collin D'Silva as division president, and will be based in Fremont, CA, USA.
The Transient MS system, specifically designed for the analysis of transient gas events at pressures near atmosphere, has been introduced by Hiden Analytical.
Thermo Fisher Scientific is providing the Scottish Metabolomics Facility (ScotMet) with technology to advance the field of metabolomics. ScotMet is funded by the Scottish Universities Life Science Alliance (SULSA) and is a state-of-the-art facility run jointly by the Universities of Glasgow and Strathclyde.
As well as the extensive exhibition of more than 1000 international exhibitors, Analytica also offers the Analytica Conference, whose slogan is "Talking Science—Today's Knowledge for Tomorrow's Applications". This is held on the first three days of the fair (23–25 March) and features four plenary presentations and 23 symposia with speakers from Germany and abroad.