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Professor Pauline Rudd, of the National Institute for Bioprocessing Research and Training (NIBRT) in Dublin, Ireland, has received an Agilent Thought Leader Award in support of her emerging glycomics research. The award includes a grant of funding and instruments to the NIBRT. The goals of the research are to develop novel approaches to analyse protein glycosylation which will assist in the characterisation of recombinant protein drugs, and to study potential glycan biomarkers associated with disease using liquid chromatography/mass spectrometry.
A new technique to analyse fingermarks from crime scenes has the potential to give crucial additional details about a suspect such as their medications, diet, the time at which they accidentally left the fingermark and can even be used to detect any substances they might have touched, such as traces of cocaine. These extra details can be important background information in a criminal investigation, especially if the suspect's fingerprint is not on the police database. It is hoped the technique will compliment current fingermark detection techniques and assist in criminal investigations.
Doping remains a problem throughout sport despite increases in technology to catch the cheats and increased sampling of competitors. At the World Cup, due to start on 11 June, two mass spectrometry companies are providing instrumentation for the anti-doping labs. AB Sciex is providing LC-MS/MS instrumentation and Agilent, GC/MS systems.
A new mass spectrometry-based method allows the identification of N-glycosylated protein sites in different tissues in a highly efficient way. It has enabled the identification of 6367 N-glycosylated protein sites.
The Aquatek 100 Waters-only Autosampler is now available from Teledyne Tekmar. It is a purge and trap autosampler that automates the sample preparation steps for the analysis of liquid samples using a fixed volume sample loop filled using a pressurisation gas.
Shimadzu Scientific Instruments has partnered with Ceres Nanosciences and Nonlinear Dynamics to develop the Nanotrap Biomarker Discovery Platform which gives researchers the ability to enrich, preserve and screen low-level biomarkers directly from complex biological samples.
The HPR-40 from Hiden Analytical is a research-grade mass spectrometer system which provides for real-time analysis of dissolved gases and vapours in aqueous solutions such as respiratory gases and hydrocarbon production.
The new SplitFlow 50 from Pfeiffer Vacuum is a small, powerful turbopump that is suitable for use in analytical applications.
Waters Corporation presented Professor Sarah Trimpin of Wayne State University, Detroit, MI, USA, with the ASMS 2010 Waters Research Award, an award presented annually that recognises scientific achievement in mass spectrometry. The award presentation took place at the Salt Palace Convention Center during ASMS.
Elemental and isotope analysis of the metals in ancient artefacts such as the prutah shown here sometimes can pinpoint the places where the metal was mined. This can be combined with historical sources to determine when the coin was likely struck. Archaeologists can use the evidence to identify or narrow date ranges of historical significance.
Xevo G2 QTof is a next-generation benchtop exact mass MS/MS mass spectrometer and is the first Xevo time-of-flight mass spectrometer to feature Waters QuanTof technology, currently only available with Waters SYNAPT G2 MS and G2 HDMS mass spectrometers. This technology brings research-grade quantitative and qualitative analytical performance to research, academic and industrial laboratories.
The Waters Xevo TQ-S tandem mass spectrometer represents a step change in targeted quantitative UPLC/Multiple Reaction Monitoring (MRM) analysis. This system is capable of accurately measuring target compounds in complex samples at femtogram levels or below. The Xevo TQ-S is designed for UPLC/MS/MS applications such as biological and medical research, bioanalysis, food safety, environmental monitoring and forensics testing where speed, sensitivity, and accuracy are of paramount importance.
Agilent Technologies Introduces Triple Quadrupole LC/MS System Delivering Tenfold Sensitivity Increase
Agilent Technologies has announced the 6490 Triple Quadrupole LC/MS System with iFunnel technology. iFunnel technology revolutionises the process of atmospheric pressure ion sampling, driving large sensitivity gains for most applications. The new system has a 25% smaller footprint than previous models, with a sensitivity specification that is 10 times higher.
Agilent Technologies and Stemina Biomarker Discovery Announce Efforts to Accelerate Stem Cell Metabolite Biomarker Discovery
Agilent Technologies and Stemina Biomarker Discovery have announced efforts to accelerate Stemina’s metobolomic research. Stemina uses metabolomic analysis of stem cells for the discovery of biomarkers for use in drug screening, drug development and drug development.
Agilent Technologies has introduced the Agilent Forensic Toxicology Application Kit for its liquid chromatography/hybrid quadrupole-time of flight mass spectrometry (LC-QToF MS) systems. The application kit allows users to quickly and easily set up screening experiments that produce high-confidence results.
Shimadzu Scientific Instruments has partnered with CovalX to offer the AXIMA MegaTOF, an integrated MALDI solution for ultra high-mass applications, including protein complex characterisation, therapeutic protein aggregates, antibody–antigen interactions, polymer analysis and high mass bioimaging.
Bruker has announced a novel MALDI molecular imaging system based on the high performance of the solariX FTMS. The new MALDI-solariX combines the extreme analytical performance of the solariX FTMS (resolving power > 1,000,000 at m/z 400 at 7.0 tesla field strength) with a robust and highly sensitive MALDI source to provide an unrivalled platform for high performance molecular imaging of small molecules (e.g. drug, metabolites, lipids) in tissue.
Bruker and several collaborating scientists are presenting a number of milestone achievements in the analysis of intact proteins, including the direct sequencing and characterisation using Bruker's new maXis ETD system. The high mass accuracy, resolving power and dynamic range which are essential to dissect complex patterns of product ions in protein fragmentation allowed, for the first time, performing ETD-based tandem mass spectrometry on biomolecular ions above 60 kDa routinely. These results represent a new record for the mass spectrometric sequencing of intact proteins and unequivocally demonstrate the dramatic advantages of maXis ETD technology in ETD-based top-down protein structural analysis.
Bruker Introduces MS Workstation 7 Software for New Chemical Analysis Gas Chromatography Triple-Quadrupole Mass Spectrometers
Bruker Daltonics' new Chemical Analysis business announced the release of MS Workstation 7, the next generation software package for the newly acquired 3x0 series GC triple-quadrupole (GC-QQQ) mass spectrometers. MS Workstation 7 features Scheduled Multiple-Reaction Monitoring (s-MRM), which facilitates method development, maintenance and data reduction tasks for challenging multi-component methods.
JEOL USA have introduced of the company’s first commercially available MALDI-ToF mass spectrometer, the JEOL JMS-S3000 SpiralTOF. The SpiralTOF has new ToF ion optics with an extended flight length in a compact footprint, delivering a resolving power of greater than 60,000 (FWHM) over a wide mass range of m/z 10–30,000.