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The use of liquid chromatography tandem mass spectrometry for the investigation of suspected (pesticide) poisoning of vertebrate animals and beneficial insects
This article explains the challenges in pesticide residue analysis of samples associated with suspected poisoning incident investigations, including the wide range of specimens and pesticides that need to be considered.
In this article we learn of a new definition for “bath salts”, and how modern mass spectrometry instrumentation can provide rapid and quantitation of these “designer” drugs.
This article shows that pyrolysis techniques, in combination with spectroscopy, are helping our understanding of how the organic matter in our solar system came to be. Fascinatingly, they also show how secondary processing of meteorite materials seems to enhance the abilities of atmospheres to host life on planetary surfaces as well as providing the raw materials from which life could originate.
Comes with a heated gas cell, transfer lines, transfer optics and a dedicated MCT detector encased in a fully purgeable external module. Zero-volume fittings are used to connect the GC column to the transfer column and the transfer column to the GC detector.
A bundle of solution packages which consist of a mass spectrometer, software, training, validation services and a liquid chromatography system which includes the Eksigent ekspert ultra 100 and 100-XL systems, which are analytical flow rate systems.
A person-portable capillary gas chromatoraph-toroidal ion trap mass spectrometer with high-speed temperature programming and a miniature toroidal ion trap mass spectrometer with a nominal mass resolution over a mass range of 50 Da to 500 Da. It is totally self-contained, weighs less than 32 pounds with all accessories, is battery operated and has on-board helium GC carrier gas supply cartridge.
A chemical threat detector that combines high-speed, high-resolution gas chromatography and a miniaturised toroidal ion trap mass spectrometer in a portable device. Designed to enhance military and emergency response capabilities in the field, it can confirm the presence and identity of chemical warfare agents and toxic industrial chemicals in gases, vapours, liquids and solids.
GC/MS system with ion optics optimised with high-performance quadrupole and Shimadzu’s Optdesign simulation program. Fully automated MS tuning allows users to optimise parameters easily and constantly ensure stable mass spectra. Maximum flow rate is 4 mL min–1 giving users the ability to select from a variety of columns. An optional direct injection probe is available.
The Federation of Analytical Chemistry and Spectroscopy Societies (FACSS) has announced the winners of the 2011 FACSS Innovations Awards. The FACSS Innovation Awards showcase the newest and most creative science debuted orally at a FACSS-organised conference. Shortlisted finalists competed in front of expert panels at the 2011 FACSS conference in Reno, NV, USA (2–7 October 2011). The panel commended the high quality of entries and selected four equal awardees.
Combining liquid chromatography time-of-flight mass spectrometry for water screening with software tools to identify pesticides and their metabolites
Monitoring drinking water quality poses many challenges and the authors describe their approach that combines instrumental developments with new software.
Waters has introduced an addition to its vials product line. The TruView LC/MS certified vials include the stringent dimensional tolerances, UV and MS cleanliness tests required for the company's LC/GC and LC/MS certified vial lines. An additional feature of TruView vials is that the glass surface exhibits low polar analyte adsorption. The vials are manufactured under tightly controlled process conditions that limit the concentration of free ions on the surface of glass. Low levels of free ions on the surface of glass result in low analyte adsorption. Applications involving sensitive MS/MS spectrometers operate at analyte concentrations of ng mL–1 to pg mL–1 levels. At these concentrations, analyte adsorption can compromise analytical results. The TruView certified vials are tested for high recovery of analyte at 1 ng mL–1 concentration using UPLC/MS/MS (MRM) and yield little adsorption.
Applications of mass spectrometry in the clinical area have increased significantly in recent years and continue to expand. The complexity of analyses has also increased, with work being undertaken in clinical labs that would have been the reserve of research labs a few years ago.
Liquid-phase analytical applications of UV-visible broadband cavity-enhanced absorption spectroscopy (BBCEAS)
BBCEAS is a new cavity-based absorption technique that uses broadband sources rather than lasers. This offers potential improvements in signal-to-noise but often lower spectral resolution compared to techniques where the laser wavelength is scanned. The article concentrates on liquid-phase applications, an interesting new area since most cavity-based absorption studies have been performed on gas-phase species up to now.
The new TLC-MS interface from CAMAG is a versatile instrument which is capable of isolating unknown compounds from a TLC/HPTLC plate and introducing them into a mass spectrometer for substance identification or structure elucidation. It can be connected to any brand of LC-coupled mass spectrometer and is compatible with all common HPLC-MS systems. Features include rapid and convenient extraction directly into your MS, identification of unknown substances, confirmation of target compounds, offering semi-automatic performance, reproducible results and detectability similar to HPLC-MS, compatibility with most common TLC/HPTLC layers and enables extraction into vials for NMR or (ATR) FT-IR, static nanospray, direct inlet EI-MS and MALDI.
Peak Scientific has introduced the Fusion 1010, a generator that provides both zero nitrogen and zero air in a single system. The new generator supports both GC-ECD and GC-FID applications and may also be used for THA applications. It essentially combines two technologies to produce zero nitrogen (ultra-high purity nitrogen with no hydrocarbons as methane) and zero air (air with no hydrocarbons as methane) from two separate outlets. The system produces high purity results, even in highly polluted environments and hydrocarbons will not cause any higher baselines. Other features include a “Rapid Start” function that allows the system to be operational again soon after a power cut and there is no need to recalibrate applications, giving consistent and reliable analysis results.
Thermo Fisher Scientific has published an application note entitled Confirmation and Quantitation of an Expanded Panel of Sympathomimetric Amines in Urine Using Single Quadrupole GC/MS which describes a method for the confirmation of amphetamines in urine in accordance with recently updated US Substance Abuse and Mental Health Service Administration Mandatory Guidelines for Federal Workplace Drug Testing Programmes.
Thermo Fisher Scientific
Thermo Fisher Scientific has developed a new method for sensitive, accurate and reproducible quantitation of low levels of PFCs in human breast milk. Using selected reaction monitoring and highly-selective reaction monitoring on a UHPLC/MS platform enables reliable and robust detection of PFCs at ppt concentrations. The new method is detailed in an application note entitled Sensitive and Accurate Quantitation of Perfluorinated Compounds in Human Breast Milk using Selected Reaction Monitoring Assays by LC/MS/MS. Using the integrated UHPLC/MS platform, separation of the six PFC analytes in a spiked human breast milk matrix was achieved within nine minutes. As the majority of interferences from matrices elute early at void volume, elution of the first compound at 3.64 minutes ensured a robust quantitation method.
Thermo Fisher Scientific