Foss NIRSystems is offering a new 12 mm BioProcess probe optimised for real-time in situ monitoring of mammalian cell culture growth media in bioreactors. With a variable pathlength that can be optimised for culture media, this novel design is autoclavable or sterilisable-in-place. The small diameter probe is designed for use in standard instrument ports in benchtop biorectors and can be adapted for scale up to pilot plant and manufacturing reactors. Real-time analysis of nutrients and metabolites will lead to optimised cell culture performance, increased cell viability and bioprocess understanding. Up to nine probes can be multiplexed to one Foss XDS Process Analytics NIR analyser, which can track key low concentration analytes in the culture growth media, enabling optimisation of the fermentation. Feedback control is available through OPC or digital protocols.

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