Understanding the extremely fast atomic mechanisms at work when a protein transitions from one shape to another has been an elusive scientific goal for years, but an essential one for elucidating the full range of protein function. How do proteins transition between distinct shapes without unfolding in the process? Until now, this question has been a hypothetical one, approached by computation only rather than experimentation. In a study in Cell (doi: 10.1016/j.cell.2009.11.022), researchers reveal for the first time computationally and experimentally the molecular pathway that a protein takes to cross the energy barrier. The study reports how folded proteins can efficiently change shape while avoiding unfolding, a critical requirement for any protein in the cell.
Bruker BioSpin has installed the world’s first 1000 MHz ultra-high field NMR AVANCE™ spectrometer at the Centre de Resonance Magnétique Nucléaire à Très Hauts Champs (CRMN) in Lyon, France (a joint research unit of CNRS, Ecole Normale Supérieure de Lyon and Université Lyon 1). The AVANCE 1000 system incorporates a 23.5 Tesla superconducting magnet, and offers exciting research opportunities, both to the CRMN and to other French and European scientists who will access this unique facility.
In structural biology, the only technique available to predict the three-dimensional structure of large complex molecules in solution, such as proteins and DNA, is nuclear magnetic resonance (NMR) spectroscopy. To improve the techniques behind these predictions, the “eNMR” project has launched a new initiative. In September’s Nature Methods (doi: 10.1038/nmeth0909-625) the project issued an invitation to the entire biomolecular NMR community to participate in a large scale test of modern computing algorithms. This community-wide “contest” will potentially improve efficiency, reproducibility and reliability of NMR structure determination. eNMR will be using the Enabling Grids for E-sciencE infrastructure to power their analysis.
New spectra, obtained with the SPIRE, PACS and HIFI instruments of the European Space Agency’s (ESA) Herschel Space Observatory during the performance verification phase, have been released by ESA and the instrument teams. Taken together with earlier images the observatory is now on the way to demonstrating that the promised imaging and spectroscopic capabilities are being met.
Agilent Technologies has purchased the MassCode Tag technology from Eurofins MWG Operon, which includes trademarks and intellectual property including patents. Agilent will usse the MassCode Tag technology to develop new research products for pathogen identification. Eurofins MWG Operon will continue as a supplier of the core component for the new products. www.agilent.com, www.operon.com
Cerno Bioscience and Agilent Technologies will jointly market Cerno’s MassWorks calibration software to Agilent GC/MSD ChemStation users. The calibration software increases the mass accuracy of Agilent’s single quadrupole GC/MSD sufficiently to identify unknown compounds. www.agilent.com/chem/gcmschemstation, www.cernobioscience.com/products.html
Page 14 of 41
Free print subscription
tesfaye saidthe NIR spectroscopy reduced the cost... 2 months ago
fred isaboke saidWant to inquire about the specificati... 9 months ago
Markus Rupprecht saidDear Tony Davies,
thank you so much f... 11 months ago
corriou saidI have read with interest the text, b... 1 year ago
Kim H. Esbensen saidre. WDXRF possibilities to map hetero... 1 year ago
- Atomic absorption
- Atomic emission
- Ion mobility
- Laser spectroscopy
- Mass spectrometry
- Near infrared
- NMR ESR EPR
- North America
- Related equipment
- RMs and standards
- Separation science
- South America
- Surface analysis
- X-ray spectrometry