Warwick researchers solve 40-year-old FT-MS phasing problem

Scientists at the University of Warwick have developed a computation which simultaneously doubles the resolution, sensitivity and mass accuracy of Fourier Transform Mass Spectrometry (FT-MS) at no extra cost.

 

Researchers in the University’s Department of Chemistry have solved the 40-year-old phasing problem which allows plotting of spectra in absorption mode. This advance can be used in all FT-MS instruments including FT-ICR, Orbitrap and FT-ToF instruments and will have applications in proteomics, petroleum analysis, metabolomics and pharmaceutical analysis among other fields.

Professor Peter O’Connor, who co-developed the method, said: “We have vastly improved the quality of data available at no extra cost. FTMS is used extensively in the fields of pharmaceuticals, healthcare, industry, natural resources and environmental management so this breakthrough represents a real step towards improving research across the board in these areas.”

The method is detailed in the study “Absorption-Mode: The Next Generation of Fourier Transform Mass Spectra” published in Analytical Chemistry doi: 10.1021/ac3000122). The paper is co-authored by Professor O’Connor, Yulin Qi, Mark Barrow and Huilin Li from the University of Warwick.

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