This is Tony’s last column for Spectroscopy Europe. It is explores an idea that he has been developing for over 30 years, although as Tony points out the story starts around 3500 years ago.
Peter Jenks seeks to show where it is important to check the CRM or RM you are using includes a clear statement of commutability, and when and where it can be largely ignored.
Hans Lohninger and Johannes Ofner describe “Multisensor hyperspectral imaging as a versatile tool for image-based chemical structure determination”. They describe the features of a software package that allows the combined analysis of hyperspectral data from different imaging techniques. This multisensor approach providing complementary information has many advantages.
“Elucidating structural and compositional changes in plant tissues and single cells by Raman spectroscopic imaging” is the topic of the next article by Batirtze Prats Mateu, Barbara Stefke, Marie-Theres Hauser and Notburga Gierlinger. Understanding plant cells is important for the best use of plants in traditional and new applications. Raman spectroscopic imaging represents one of the best ways to unravel the molecular structure in the native environment of plant tissues.
In the Quality Matters column, Peter Jenks and John Hammond look “Into the future: changes to ISO 17025 and ISO Guide 34”. There is a lot happening at present around ISO/IEC 17025 and ISO Guide 34, which together provide the framework for the development and use of certified reference materials in analytical laboratories around the world. John reports from the recent 37th meeting of the Reference Material Committee of ISO (ISO/REMCO) and provides an update on the topic of “commutability”.
Robert Bradshaw and Simona Francese tell us about “Matrix–assisted laser desorption ionisation tandem mass spectrometry imaging of small molecules from latent fingermarks“. Especially when looking at small molecules in fingermarks, isobaric species can be a problem and this has the potential to affect the outcome of any court case if not handled appropriately. Tandem mass spectrometry can be used as an alternative to high-resolution MS and ion mobility.
Orthogonal spectroscopic techniques for the early developability assessment of therapeutic protein candidates” are described by Patrick Garidel, Anne Karow and Michaela Blech. Due to its cost and time implications, in the early development phase of drug discovery the use of othogonal techniques, based on different physical observables, is important for correct decision-making.
Graeme Clemens, Benjamin Bird, Miles Weida, Jeremy Rowlette and Matt Baker consider “Quantum cascade laser-based mid-infrared spectrochemical imaging of tissues and biofluids”. Mid-infrared spectroscopic imaging has been applied to many biological problems and even has the potential to improve cancer patient outcome. The use quantum cascade lasers simplifies the instrument and allows for the use of detectors that do not require cryogenic cooling. They demonstrate applications on tissue and biological fluids.
- Shedding light on plant biology by Fourier transform infrared spectroscopy of pollen
- The last furlong (5). Classification and identity testing
- Have you the time for another conference?
- Broadband photon time-of-flight spectroscopy as a prospective tool in biomedicine and industrial process and quality control
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- Application of Raman and photoluminescence spectroscopy for identification of uranium minerals in the environment
- X-ray fluorescence for cultural heritage: scanning biochemical fingerprints in archaeological shipwrecks
- Optical spectroscopy in therapy response monitoring: an awakening giant
- Rheo-nuclear magnetic resonance spectroscopy: a versatile toolbox to investigate rheological phenomena in complex fluids
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- Atomic absorption
- Atomic emission
- Ion mobility
- Laser spectroscopy
- Mass spectrometry
- Near infrared
- NMR ESR EPR
- Related equipment
- RMs and standards
- Sample prep
- Separation science
- Surface analysis
- X-ray spectrometry