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Orthogonal spectroscopic techniques for the early developability assessment of therapeutic protein candidates” are described by Patrick Garidel, Anne Karow and Michaela Blech. Due to its cost and time implications, in the early development phase of drug discovery the use of othogonal techniques, based on different physical observables, is important for correct decision-making.
Graeme Clemens, Benjamin Bird, Miles Weida, Jeremy Rowlette and Matt Baker consider “Quantum cascade laser-based mid-infrared spectrochemical imaging of tissues and biofluids”. Mid-infrared spectroscopic imaging has been applied to many biological problems and even has the potential to improve cancer patient outcome. The use quantum cascade lasers simplifies the instrument and allows for the use of detectors that do not require cryogenic cooling. They demonstrate applications on tissue and biological fluids.
Shedding light on plant biology by Fourier transform infrared spectroscopy of pollen” by Boris Zimmermann and Achim Kohler. Currently, pollen identification is mostly done under a light microscope. FT-IR spectroscopy of pollen grains provides rapid and simple identification of pollen, with the added benefit of providing environmental information.
Tony (A.M.C.) Davies continues on his last furlong, this time considering “Classification and identity testing”. As well as some interesting insights into the analytical lab in the late 1960s, he gives his opinion on various chemometric techniques and on identity testing, as well as thoughts on future development.
Peter Jenks is off to a conference. He describes the history of the Biological and Environmental Reference Materials (BERM) series of conferences and concludes that they still are important for all of us 30 years after their start. He urges you to attend the next, in October 2015 in the USA.
The analysis of turbid samples is increasingly important, not least due to their widespread occurrence in natural samples. Dmitry Khoptyar, Sören Johansson, Staffan Strömblad and Stefan Andersson-Engels show “Broadband photon time-of-flight spectroscopy as a prospective tool in biomedicine and industrial process and quality control”. The authors describe their recent development of a broadband spectrometer for evaluation of absorption and scattering spectra of very diverse turbid materials in the visible and close-near infrared (NIR) regions and its application with milk, cheese and paper samples.
Knowledge about the particles in the air is important because of their effect on our health and their impact on our climate through cloud formation and transport of nutrients into the oceans. Ursula Fittschen describes “Strategies for ambient aerosols characterisation using synchrotron X-ray fluorescence: a review”. This technique can provide elemental determination and speciation of aerosol particulates with limits of detection in the pg m–3 range for many elements.
Ronnie Gallagher tells us about “Atomic dielectric resonance”. This technique has many applications in analysis of features below the Earth’s surface, both exploration for water, oil, gas and minerals, as well as archaeological and architectural sites where its non-destructive nature is of great value. It also has been used to identify some Creutzfeldt–Jakob diseases in humans.
Another area of application of XRF, “Determination of elemental distribution or heterogeneity by X-ray fluorescence”, is considered by Christopher Shaffer and Didier Bonvin. The ability of modern X-ray spectrometers to perform small spot analysis as well as mapping has opened up new applications in non-homogeneous samples. The authors show applications in metals, precious alloys as well as rocks.
Page 9 of 28
- Analysis and sequencing of nucleic acids by matrix-assisted laser desorption/ionisation mass spectrometry
- Investigation of the decomposition of organic solvent-based lithium ion battery electrolytes with liquid chromatography-mass spectrometry
- Raman microspectroscopy provides access to compositional and microstructural details of polycrystalline materials
- Are they among us? Screening for drugs of abuse and new psychoactive substances in pooled human urine and wastewater samples
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- Atomic absorption
- Atomic emission
- Ion mobility
- Laser spectroscopy
- Mass spectrometry
- Near infrared
- NMR ESR EPR
- North America
- Related equipment
- RMs and standards
- Separation science
- South America
- Surface analysis
- X-ray spectrometry