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Tony Davies and Steven Brown explore the solid-state nuclear magnetic resonance spectroscopy facilities at the UNiversity of Warwick, UK.
International standards need to keep pace with the innovation in analytical equipment and practices. For example, many of the advances in nuclear magnetic resonance (NMR) spectroscopy reported in this journal in recent years have yet to find themselves mirrored by updates in the respective Recommendations of the International Union of Pure and Applied Chemistry (IUPAC), nor in the many and varied proprietary recommended reporting formats of the different peer-reviewed primary scientific journals. Not that every innovation needs to be “standardised”: with the speed of many developments it is important to find the right balance between reacting to real movements in a field and enshrining a short-lived fad in a IUPAC Recommendation.
A superconducting insert coil made from a copper-oxide-based ceramic, YBCO, has raised the magnetic field achievable to 25 Tesla.
New method allows hyperpolarised xenon gas, to be dissolved into minute samples of substances without disrupting their molecular order during NMR spectroscopy.
Magritek have released new solutions that enable straightforward reaction monitoring on the Spinsolve benchtop NMR spectrometer.
The protein α-synuclein plays an important role in Parkinson’s and other neurodegenerative diseases. Although a considerable amount is known about the structure of the protein within the Parkinson’s-typical amyloid deposits, nothing was known about its original state in the healthy cell up to now. High-resolution nuclear magnetic resonance and electron paramagnetic resonance spectroscopy have helped to visualise the protein in healthy cells.
Fake or low-quality medicines and food supplements are a continuing global problem in developing nations, and indeed the developed world is not immune. A low-cost, portable prototype using nuclear quadrupole resonance spectroscopy can detect tainted medicines and food supplements.
This product focus is on Molecular Spectroscopy.
Oxford Instruments and Green Imaging Technologies have introduced the GeoSpec2+
Deutero have introduced a simple glass funnel suitable for 5-mm NMR tubes
Enhanced version of the FoodScreener for Wine Profiling that provides analysis of relevant regions in France, Italy and Spain. It also determines further authenticity parameters such as grape variety, vintage year and possible water addition. The system has been extensively validated and offers a rapid and fully automated tool to check wine quality and authenticity.
Software that enables the adjustment of experimental parameters based on real-time data during the analysis of chemical processes by NMR spectroscopy. Experts and non-experts can set up, monitor and adjust key experimental parameters. The software provides a complete workflow from data acquisition to project report with the ability to export data in multiple formats for additional processing.
FoodScreener Module for Honey
The most recent module of the FoodScreener product line allows the simultaneous identification and quantification of many honey characteristics, including sugar, acid and amino acid content as well as fraudulent addition of different types of syrup or other sugar solutions. The database developed for the module contains thousands of samples from around the world.
NMR spectrometer with high accuracy RF circuitry using digital high frequency technology. Is 43% smaller than previous models and performance features critical to NMR data collection have been improved by several orders of magnitude. A complete set of high-performance NMR probes are available for it, including a new high-sensitivity liquid-nitrogen probe capable of variable temperature experiments from –40°C to 150°C.
Spinsolve Reaction Monitoring
The Spinsolve benchtop NMR systems are seeing growth for on-line reaction monitoring, where reactants may be pumped continuously from the reactor to the NMR spectrometer and back again to provide reaction kinetics: determine reaction end points, identify intermediates and products.link.spectroscopyeurope.com/27-02-082
Rheo-nuclear magnetic resonance spectroscopy: a versatile toolbox to investigate rheological phenomena in complex fluids
“Rheo-nuclear magnetic resonance spectroscopy: a versatile toolbox to investigate rheological phenomena in complex fluids” is Claudia Schmidt’s topic. Rheology is an important science, and NMR has a number of uses within it. However, challenges remain for the simultaneous measurement of rheological and NMR parameters.
Magritek has introduced the Spinsolve Phosphorus, the first 31P capable benchtop NMR spectroscopy system.
The Tony Davies column is a joint effort by Tony (A.N.) Davies, Mohan Cashyap, Bob Lancashire and Bob Hanson on “Exploring distributed, multi-server 1H NMR prediction”. This is the second part of the column’s investigation into the use of cloud-based services in the analytical arena. It describes a web page linking services from multiple sites on both sides of the Atlantic to deliver molecular structure drawing, 3D structure representation, name to structure conversion and display of data generated by linking chemical structures to 1H NMR prediction. May I reiterate Tony and Mohan’s plea for information on such cloud-based solutions, whether commercial or not. These can be sent to me (firstname.lastname@example.org) and I will pass them on.
Mathieu Duval raises the question “Dating fossil teeth by electron paramagnetic resonance: how is that possible?”. Whilst we are all familiar with 14C dating, the use of EPR is less well known. In fact, there are less than 10 laboratories in the world able to carry out EPR dating of fossil teeth!
Tony (A.N.) Davies is getting excited by GHz NMR. These new high fields offer tantalising new areas of research but at a cost that generally requires their purchase by Government-funded centres of excellence. He argues that continued funding of such projects is essential, especially in difficult economic times.
Nuclear magnetic resonance-based approach to fruit characterisation: the case studies of kiwifruits and peaches
Many analytical methods have been used to control the quality, authenticity and origin of fresh fruit. NMR methodologies yield a comprehensive metabolic profile, provide direct structural information regarding individual metabolites in the mixture and also give information regarding the water state in the tissue. This is useful in discriminating various fruits varieties, in investigating nutritional properties, in monitoring the development of the fruit and in assessing the optimum harvesting time.
Peter Jenks has discovered quantitative NMR. in his article titled “NMR: is it the future for the analysis of organic molecules?”. If only it wasn’t so expensive, it might be the perfect method to certify pure organic compounds.
The Winescreener, a high-performance FT-NMR-based screening system that delivers rapid and cost-effective quantitative targeted and non-targeted statistical analyses of wine, is now available from Bruker. The system features a large number of parameters delivered within a single, completely automated, push-button analysis with minimal sample preparation. Quantification of 25 relevant components is delivered on one measurement and, in addition, both quality and safety are assessed by non-targeted screening. The transferability of the method, based on standard operation procedures, guarantees identical results across different analysis laboratories and, due to its self-learning nature, the solution will further increase its capabilities as new wine analyses are integrated on a global basis.
Benchtop NMR spectrometer that provides identical spectra to standard NMR spectrometers yet weighs only 10½ pounds and costs in the region of US$25,000. Sample volume is 20 µL and the spectrometer is controlled via a web browser. Data can be downloaded for use in any standalone software package.