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Scientists at EPFL have shown how a light-induced force can amplify the sensitivity and resolution of SERS for the study of single molecules.
A report on the 12th Confocal Raman Imaging Symposium held in Ulm, Germany, September 2015, which covered a fascinating range of applications of the technique.
Kidney stones rank among the most common illnesses. Their recurrence may be prevented with the right post-operative care. However, for this to be effective, the composition of the stones needs to be known. Fraunhofer researchers are developing a Raman spectroscopy based system for rapid analysis of urinary stones immediately after the surgical procedure.
The new and improved S11850-1106 and S11851-1106 back-thinned CCD linear image sensors from Hamamatsu Photonics have improved etaloning characteristics and high sensitivity designed for spectrometry applications.
Horiba Scientific and AIST-NT now offer a solution that addresses the instrumentation concerns of tip enhanced Raman scattering (TERS).
Graphene has been receiving a large amount of interest as its commercial possibilities begin to be realised. Now, with hundreds of companies offering commercial graphene production, analytical measures of graphene quality are required. Raman spectroscopy can be used to “understand the number of layers, strain, doping and importantly the level of disorder present in graphene”, which is described in this article: “Graphene characterisation and standardisation via Raman spectroscopy” by Andrew Pollard and Debdulal Roy.
The National Physical Laboratory (NPL) in the UK has used tip-enhanced Raman spectroscopy to map catalytic reactions at the nanoscale for the first time.
Tornado Spectral Systems has released the HyperFlux P.R.O. Plus process Raman analyser
Automated detection of counterfeit drugs using multimodal spectroscopy and advanced web-based software platforms
In the Tony Davies Column, we learn about “Automated detection of counterfeit drugs using multimodal spectroscopy and advanced web-based software platforms”. With the increase in trafficking of counterfeit medicines and other products, there is a need for definitive results from an on-site analyser useable by customs officers. The German authorities have commissioned the development of a multi-modal, transportable inspection system, including intelligent data processing and evaluation, for fast spectroscopic recognition of illicit drugs and counterfeit medicines. This is described in the column.
Raman microscopy is being used alongside high-resolution X-ray diffraction to unpick the reasons for crystallographic defects in SiC bulk crystal and epitaxial film, which limit the commercialisation of SiC devices.
Canadian researchers have used SERS to screen blood samples for molecular traces that indicate the presence of precancerous polyps in the colon, a key warning sign for colon cancer. Their results may yield a cheaper and less invasive initial screening test for colon cancer that could complement colonoscopy, though further clinical trials will need to demonstrate the safety and effectiveness of the blood test before it is routinely used.
Raman spectroscopy helps lithium-air batteries live up to their promise: we could one day be driving electric cars 500 miles or more without recharging, or using laptops for weeks without having to plug in. They could also replace lithium-ion batteries, currently the standard in many consumer electronics.
A Lab-on-a-Disc platform combined with Raman microscopy and developed by a German and Irish team of researchers can dramatically cut the time to detect bacterial species that cause urinary tract infections—a major cause of sepsis—from 24 hours to within 70 minutes.
UCLA, USA, are combining Raman microscopy with scanning electron microscopy (SEM) to study archaeological textiles and fibres.
A new technique combines electron microscopy and synchrotron x-rays at Brookhaven Lab to track chemical reactions under real operating conditions.
Monitoring of catalytic reactions and catalyst preparation processes in liquid phase systems by combined in situ spectroscopic methods
In situ spectroscopic methods such as infrared, Raman and UV/vis spectroscopy are powerful tools to gain insight into reaction mechanisms and catalyst actions in homogeneously catalysed reactions. These methods and combinations of them offer great potential for the real-time monitoring of reactions in the liquid phase, for mechanistic studies as well as process control and kinetics.
Mobile µRaman and µ-BioRaman
Two portable Raman microscopes that are smaller than a portable sewing machine. The reduction in size has enabled shorter, more efficient light paths, reduction in laser power and faster scanning. Both systems offer multiple sampling handling modalities (microscope slide, cuvette, vial or syringe), a fast scanning PZT stage for Raman mapping and an optional battery pack. The µRaman interfaces with Bio-Rad’s Raman ID Expert database and the µ-BioRaman uses BioTools’ own library of protein spectra.
A hand-held Raman spectrometer with patented fluorescence mitigation that enables measurement of a wide range of raw materials. Duo LASER excitation with two wavelengths provides high sensitivity across the whole spectral range, and the instrument also features automated wavenumber calibration and automated measuring tip recognition. It is also certified as a class 1M laser product.
Portable Raman system with laser excitation at 785 nm and spectral range of 65–3200 cm–1 and resolution of ~4.5 cm–1 at 912 cm–1. Detection is by a high quantum efficiency CCD array, TE-cooled to –25°C.
Hand-held Raman analyser for plastics identification. Comes pre-loaded with a user-configurable library of over 45 plastics. Can identify light and dark plastics from all major families and sub-families, and the user can add their own plastics to the library. Two rechargeable batteries provide over 4 hours of operation.
Freedom mini Raman
OEM miniature Raman spectrometer, which is robust and almost athermal. It measures 61 × 64 × 19 mm and has a spectral range of 475–1100 nm with a resolution of 0.6 nm. It can be used with many different laser wavelengths covering the popular 532 nm, 785 nm and 830 nm.
Compact and easy-to-use dispersive laser Raman microscope designed for automatic use. It uses the same software interface as JASCO’s FT-IR spectrometers allowing IR users easily to transfer to the Raman system. It uses three lasers at 457 nm, 532 nm and 785 nm and a spectrograph resolution down to 0.7 cm–1. A new fluorescence rejection algorithm is also built into the instrument.
Combines a back-thinned CCD array detector with low stray light optical design, for applications including chemical catalysis and Raman analysis. A toroidal grating corrects optical aberrations and improves stray light performance, extending linear measurement range up to 3.0 OD. Stray light performance is 0.015% at 400 nm. The Maya LSL interfaces to a computer via its USB port and couples to Ocean Optics accessories.
The inVia confocal Raman microscope can now perform transmission Raman analysis, which provides greater flexibility. Transmission Raman is an attractive method for the fast, quantitative analysis of bulk material homogeneity, in applications such as tablet dose and blend uniformity.
Raman spectroscopy module that can be easily integrated with most upright microscopes from Nikon, Olympus, Leica or Carl Zeiss. Available in 532 nm, 633 nm and 785 nm versions. The module includes a high sensitivity linear array detector, power attenuation with laser safety interlock and user friendly software.
Fully automated, easy-to-use Raman imaging system that includes laser wavelength selection with subsequent adjustment of all associated spectrometer and microscope components to ensure optimised system performance. It also includes absolute laser power determination and regulation in 0.1 mW steps. The UHTS 600 is a new 600 mm focal length spectrometer designed for automated Raman imaging; spectral resolution is down to 0.1 rel cm–1 at 633 nm excitation.link.spectroscopyeurope.com/27-02-092
“In vivo Raman spectroscopy of skin” is Paul Pudney’s topic. The skin is a most important part of our bodies. There is great interest in studying it to help understand the many skin diseases we are prone to, including cancer, to develop skin care products and, increasingly, as an alternative route to administer pharmaceuticals instead of through the gut. Raman spectroscopy is an exellent tool to study these, and has particular advantages in its ability to do so in vivo.
Ibsen Photonics has announced the Freedom mini Raman spectrometer platform for integrators of analytical and process control instruments. The spectrometer is robust and almost athermal and can operate under demanding environmental conditions..
Application of Raman and photoluminescence spectroscopy for identification of uranium minerals in the environment
The “Application of Raman and photoluminescence spectroscopy for identification of uranium minerals in the environment” is described by Eric Faulques, Florian Massuyeau, Nataliya Kalashnyk and Dale Perry. Uranium forms a large number of compounds and complexes, and these are most helpful in the study of uranium, its chemistry and transport in the environment. Raman and photoluminescence spectroscopy provide complementary information and are powerful tools for direct speciation of uranium and identification of natural uranyl minerals relevant to the environment.