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The single cell Raman spectrum (SCRS) enables cell probing and sorting to study phenotypes and ecophysiology of single cells and explore individual cells in situ in a label-free and non-destructive manner.
Highlighting the importance of utilising the polarisation properties of resonance Raman scattering in obtaining molecular information
In resonance Raman scattering (RRS), the amount of structural and chemical information deduced can be increased by analysing the polarisation of the inelastically scattered light, including the degree of molecular aggregation in bio-molecules in their natural environment.
There are a number of approaches, and by combining FT-IR imaging methodology with microfluidics devices, the opportunity to study live cells by FT-IR imaging in controlled environments is now possible.
Detection of thiabendazole applied to organic fruit by near infrared surface-enhanced Raman spectroscopy
Thiabendazole (TBZ) is a chemical fungicide and parasiticide used to prevent mould, blight and other diseases resulting from long transportation and storage, largely used as an ingredient in waxes applied to the skins of citrus fruits. The authors describe their work using near infrared-surface-enhanced Raman spectroscopy and conventional Ag nanoparticles, which showed that TBZ was found both on organic fruit and at levels higher than regulations allow.
Fuels and the taxes raised from their sale are a big business around the world. To control smuggling, counterfeiting, theft and product diversion, markers can be placed in the fuel. The use of a SERS active compounds as markers is described as well as the development of a portable instrument for detection of the markers in the field.
This article explains what is represented in a Raman spectrum of carbon nanotubes and how to optimise the measurement. There is actually significant diversity within samples of nanotubes which affects both the material properties and the Raman spectrum of the material.
An important use of Raman spectroscopy to help understand the impact of traffic on roadside soils and plants
Even though lead in fuel has been banned for a number of years, it is still present in by the roadside, as are many other pollutants from vehicles. The combination of Raman spectroscopy and µ-ED-XRF is of particular value. The advantage Raman has is in the possibility of focusing on individual grains, thereby obtaining the spectrum of each grain that comes from traffic-emitted particles.
This Product Focus is on Raman Spectroscopy; a number of companies have provided information on their key products, their applications and features.
Following lipids in the food chain: determination of the iodine value using Raman micro-spectroscopy
Raman spectroscopy is used to monitor the iodine value of algal-derived fish feed for its lipid content and to monitor algae samples for biofuel production.
Whilst fireworks are a great entertainment, they can also be used for illegal activities as well as potentially containing dangerous chemicals. The combination of Raman spectroscopy and SEM-EDS turns out to be a very efficient analytical method. In fact, these complementary techniques may also be used to analyse other kinds of pyrotechnic artefacts, low explosive formulations, high explosives, explosion residues etc.
Starfruit-shaped gold nanorods could enhance surface-enhanced Raman spectroscopy (SERS) by a factor of 25 compared to similar smooth nanorods.
Praveen Ashok and Kishan Dholakia of St Andrews University, UK, describe the scope of optofluidic devices that can be implemented using the waveguide confined Raman spectroscopy (WCRS) technique they have developed. I am particularly impressed by the sample size of whisky shown in Figure 2—true Scottish style!
A new line of compact fibre-optic Raman probes has been introduced by FiberTech Optica. Combining the company’s knowledge in optics, spectroscopy and manufacturing of precision fibre assemblies, the probes feature an optical configuration designed to enhance both the throughput and the quality of collected Raman spectra. Featuring high collection efficiency optics, internal filtering, about 4 mm working distance, rugged assembly and no moving parts, the probes are packaged in a steel tube about 4 mm in diameter. The design allows for almost real-time collection of data from solid and liquid samples.
A handheld Raman system for rapid identification of suspected narcotics, without direct contact for most samples. A single test for multiple controlled substances provides narcotics officers with clear, definitive results for presumptive identification with no user interpretation. Lightweight and easy to use. Captures all scan results and self check results to help expedite prosecution, and the Admin software stores all scan results with time and date stamps.
A new 3D fast imaging capability for the inVia Raman microscope. The inVia systems—with the StreamLineHR™ imaging option—can now collect and display Raman data from within transparent materials. This provides users with full 3D visualisation of their samples.
Online Raman system weighing about 12 lbs, which is easy to install even while the process is running since it operates through a sight glass. Software supports real time, in-process quality decisions presented in terms suitable for line operators. Observations, analyses and decisions are retained in accordance with industry standards for quality and regulatory compliance.
Small, quality control system for verification of tablets, capsules, bulk powders and liquids. As well as Raman spectroscopy, it analyses colour and size to provide “multi-variant” analysis. Targetted at the chemical and pharmaceutical industries.
Complete Raman software application that guides users through system set up, Raman spectrum data and map acquisition, measurement and data processing, and report generation. This new version has a redesigned interface and data browser, as well as a fully integarted Multivariate Analysis module for characterisation of complex data sets.
A new portable device designed to support law enforcement professionals to perform presumptive test on chemical substances while in challenging situations in the field. The ruggedised unit, using patented technology, identifies prescription drugs within 15 s of analysis in just three step processes.
Micro imaging Raman system for applications in biologics (solids and liquids, comparability, biosimilars, batch release testing), forensics, pharmaceuticals, polymers and semiconductors. It can measure full spectra from 3200 cm–1 to 200 cm–1 including Amide I, II and III, S–S, S–H and C–H bonds. It measures 14″ wide by 11″ high and weighs about 10 lbs (~4.5 kg).