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Researchers at the University of Konstanz, have for the first time successfully developed a novel on-line bioaffinity-electrospray ionisation (ESI) mass spectrometry (MS) approach, which enables the simultaneous label-free detection, identification and quantification of protein–ligand interactions. Combining the sam5 surface acoustic wave biosensor from SAW Instruments with ESI-MS has enabled the direct connection of protein–ligand dissociation constants (KD) analysis with their subsequent quantification and structural characterisation by MS.
AB SCIEX has expanded its commercial operations in Korea with a new direct sales organisation under AB SCIEX Korea. This expansion was made possible by an agreement with Life Science Korea (LSK) to transfer existing sales, service and marketing personnel to AB SCIEX, effective immediately.
Agilent Technologies Inc. has opened a new life sciences instruments manufacturing facility in Singapore. The facility will produce the company’s LC/MS instruments for the global market.
Bruker Daltonics has been selected by the National High Magnetic Field Laboratory (NHMFL) at Florida State University to design and build the world’s first 21.0 T Fourier Transform Ion Cyclotron Resonance (FT-ICR) magnet. The magnet will be designed in collaboration with NHMFL scientists and used in the FT-ICR programme at the lab. The contract for the magnet is valued at over $10 million, the project is funded by the National Science Foundation, and delivery of the magnet is planned for the first half of calendar year 2013.
Shimadzu has developed the LCMS-8030 which combines the power of triple quadrupole mass spectrometry with the speed to complement its UHPLC systems. The instrument features ultra-fast multiple reaction monitoring transitions, enabling data acquisition with up to 500 different channels per second.
AB Sciex has announced the launch of the TripleTOF 5600 system, a fast, sensitive, high-resolution mass spectrometer for high-performance qualitative and quantitative analysis. The system combines the quantitative capabilities typically associated with triple quadrupoles and the qualitative capabilities of a high-resolution, accurate-mass system. It has been designed to enable new and improved ways for scientists to conduct mass spectrometry experiments for a broad range of life science applications, such as discovering new drugs, detecting biomarkers and aiding in food safety and environmental analysis. Features of the system include SmartSpeed 100 Hz Acquisition, Accelerator TOF analyser for high-resolution data at high speed and high sensitivity and EasyMass Accuracy to achieve stable mass accuracy without continuous user calibrations. A suite of new application-specific software is available to enable life scientists to access new workflows for comprehensive exploration, rapid profiling and high-resolution quantitation of complex samples. Among these are MetabolitePilot software for identifying metabolites, PeakView software for processing and visualising large amounts of MS data quickly and easily and new versions of MultiQuant software, ProteinPilot, LipidView software and MarkerView software.
NLG Analytical has announced the release of its latest v-kit qualification system for LC-MS systems, suitable for single and triple quadrupole mass spectrometers. The package consists of software-driven protocols, standard operating procedures and traceable reference standards. Written on the v-kit Pro platform, the software features report creation, summary reporting and audit trail and user/manager access rights. The electronic logbook function allows the data from the entire qualification exercise to be quickly and easily assembled into a single document for storage or distribution. The kits can be provided for qualification by the user or as part of service delivery by approved v-kit service partners.
NLG Analytical Ltd
Agilent Technologies has introduced two Triple Quadrupole GC-MS Pesticide Analysers that are complete, factory-configured, highly sensitive and chemically tested systems which can quickly identify a broad range of commonly analysed pesticide residues. Version one of the analysers is designed for maximum flexibility, permitting users to add GC detectors. The system is easily scaled to shorten run times. The analyser includes a method based on Agilent's Retention Time Locked GC-MS-MS MRM database containing spectra for more than 500 pesticides. Version two delivers higher performance and shorter cycle times while consuming less carrier gas. The analysis is based on the USA Targeted Pesticide List GC/MS/MS MRM database with more than 200 pesticides. Included in each analyser is a full set of pesticide checkout samples, a promotional QuEChERS sample preparation kit and Retention Time Locked HP-5MS Ultra Inert column for reliable database matching. Also provided are a quick start guide and application note that show users how to run the analyser's screening method and a CD-ROM with examples of screening methods, data files and reports.
Agilent Technologies Europe
The new MALDI Sepsityper kit for the identification of microorganisms from positive blood culture bottles using MALDI Biotyper solution is now available from Bruker. Microbial cells are taken from an aliquot of blood culture, processed using the kit and then identified by the MALDI Biotyper. A sample can be ready for MS-based molecular identification minutes after taking the aliquot from the blood culture bottle. The workflow is recommended and optimised for blood culture bottles without any charcoal supplements as these would need to be removed by additional sample preparations steps.
Time-of-flight secondary ion mass spectrometry (ToF-SIMS) is proving to be critical for identifying and differentiating the various components of explosives. ToF-SIMS can potentially be used to differentiate between explosive manufacturers and to reveal an explosive material’s country of origin.
Latest webinar from Waters Corporation
In Search of Biomarkers: Mass Spectrometry as a Tool for Discovery
Tuesday, October 26, 2010: 15:00 UTC
08:00 PDT (USA)11:00 EDT (USA)16:00 BST (UK)17:00 CEDT (Europe)
Mass spectrometry coupled with liquid chromatography is one of the most powerful techniques for biomarker discovery due to the attributes that these tools exhibit over other methods. Of these, perhaps the most important are the sensitivity and selectivity of the method, and the facile manner in which structural information can be determined. Evidence of this can be seen in the substantial adoption of these technologies for both metabolomic and proteomic analysis. The goals of these experiments are shifting, and it is no longer sufficient to identify potential biomarkers such as endogenous metabolites, peptides, and proteins, but these species must also be quantified at low endogenous concentrations. In order to meet these challenges, new instrumentation and workflows have been developed. In this webinar, hear from experts in the field about the challenges and solutions associated with the search for biomarkers and promising analytical solutions to address them.
Find out:Strategies for simultaneous quantitative and qualitative data collection and interpretation What it means to control variability in samples and gain confidence in your biomarker discovery How statistical methods aid discovery in metabolomics How high definition mass spectrometry (HDMS) can redefine the limits of sensitivity for protein identification
Your presenters:John P ShockcorDirector of Life Sciences Business DevelopmentWaters Corporation Jim LangridgeDirector of Proteomics Business OperationsWaters Corporation
Europe is getting ready for its first unmanned visit to the surface of Mars. The first European Mars Rover on a joint mission of the American and European space agencies, NASA and ESA, will take off in 2018. The 250 kg Rover will roll over the surface of Mars at a speed of 100 m per hour. While doing so, it will inspect the surface and gather up ground and rock samples, some of them up to 2 m deep. The main goals of the so-called EXOMARS mission are to search for traces of former or present life on the earth-like planet, and to prepare for the arrival of a manned Mars landing.
Researchers at the University of California, San Diego have revealed new details about how cannibalistic bacteria identify peers suitable for consumption. The work, which employed imaging mass spectrometry, is a first step toward a broader effort to map all signalling molecules between organisms.
Kenneth Standing and Werner Ens from the University of Manitoba have won the Manning Innovation Award, which has been recognising and encouraging innovation in Canada since 1982. The award is given to Canadians who have demonstrated recent innovative talent in developing and successfully marketing a new concept, process or procedure.
Scientists at the Georgia Institute of Technology, GA, USA, have attained very promising results on their initial investigations of a new test for ovarian cancer. Using a new technique involving mass spectrometry of a single drop of blood serum, the test correctly identified women with ovarian cancer in 100% of the patients tested.
Targeting new performance enhancing drugs in doping controls: Selective androgen receptor modulators (SARMs)
Doping control authorities and sports drug testing laboratories are frequently confronted with the illicit use of performance-enhancing therapeutics and therefore various analytical strategies have been developed to detect a misused drug and/or its metabolic product(s) in blood or urine specimens. Besides the administration of clinically approved drugs prohibited in sports, new drug candidates currently undergoing early or advanced clinical trials have also been the subject of investigations concerning their prevalence and abuse by athletes.
Selected ion flow tube mass spectrometry, SIFT-MS; new horizons in real time air and breath analysis
We conceive selected ion flow tube mass spectrometry, SIFT-MS, primarily as a real-time, absolute, analytical technique that can meet the challenge of the immediate analysis of humid exhaled breath for rapid clinical diagnosis and therapeutic monitoring. This objective has certainly been achieved and the application of SIFT-MS has quickly been expanded into many other areas where real time, immediate analyses of trace compounds in air are desired, as we have demonstrated in recent reviews and which we summarise at the end of this article.
Biocius Life Sciences and Agilent Technologies have launched the RF360 high-resolution system for high-throughput screening of in vitro ADME assays.
Bruker has announced the autoflex speed MALDI-ToF mass spectrometer as a high-throughput option for microbial identification by molecular fingerprinting using its MALDI Biotyper platform.
Waters has expanded its Xevo MS instrument platform by introducing the Xevo TQ-S and Xevo G2 QTof. Combined with Waters UltraPerformance LC systems, these mass spectrometers offer scientist a combination of separations power and high levels of sensitivity, whether for compound identification, quantification and screening or for extracting the most information from small sample volumes in a single analysis.