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Tag: Mass spectrometry Ordering

Archaeologists examining late period Mayan containers have identified nicotine traces from a codex-style flask, revealing the first physical evidence of tobacco use by ancient Mayans. The study published in Rapid Communications in Mass Spectrometry reveals the flask is marked with Mayan hieroglyphics reading, “y-otoot ’u-may” (“the home of its/his/her tobacco”), making it only the second case to confirm that the text on the exterior of a Mayan vessel corresponds to its ancient use.

Monitoring drinking water quality poses many challenges and the authors describe their approach that combines instrumental developments with new software.

Due to the importance of imaging mass spectrometry in the life sciences, the Joint Committee of the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) has decided, as part of the “Imaging Mass Spectrometry in the Life Sciences” initiative, to equip nine universities with major instrumentation systems.

Tony (A.N.) Davies is impressed with the service form the UK's EPSRC National Mass Spectrometry Service Centre.

Chemical contaminants in water are of concern to all of us. This article reviews the use of mass spectrometry (MS) in environmental and wastewater analysis.

After an introduction to MALDI, DESI and SIMS, the authors describe their main applications in forensics, as well as the advantages provided in terms of sample preparation over approaches routinely used in toxicological laboratories.

The HPR series of mass spectrometer-based gas analysers from Hiden Analytical has been expanded further to include analysis of static off-line gas samples in addition to the more routine conditions of dynamic flow. New additions include the HPR-70 bench-top system for gas composition measurement of small individual discreet samples with the gas preparation stage including selectable cascade volumes for pressure optimisation over a wide spread of sample volumes and sample pressures. Samples will normally be acquired and contained off-line as the container has an isolation valve or break-seal for direct connection to the mass spectrometer. The HPR-90 system uses similar mass spectrometer stages together with a customised inlet system specifically configured for analysis of gases trapped within enclosed volumes. It is totally enclosed within a UHV-compatible evacuated vacuum vessel and is equipped with appropriate cracking or drilling facilities to enable release of the gas sample for immediate analysis. Package volumes from 10 litres down to sub-millilitres are accommodated. The systems offer a choice of manual or automated operation and include multiple calibration routines for data quantification, enabling measurement of low-level gas components to the sub-ppm level.

Waters has introduced an addition to its vials product line. The TruView LC/MS certified vials include the stringent dimensional tolerances, UV and MS cleanliness tests required for the company's LC/GC and LC/MS certified vial lines. An additional feature of TruView vials is that the glass surface exhibits low polar analyte adsorption. The vials are manufactured under tightly controlled process conditions that limit the concentration of free ions on the surface of glass. Low levels of free ions on the surface of glass result in low analyte adsorption. Applications involving sensitive MS/MS spectrometers operate at analyte concentrations of ng mL–1 to pg mL–1 levels. At these concentrations, analyte adsorption can compromise analytical results. The TruView certified vials are tested for high recovery of analyte at 1 ng mL–1 concentration using UPLC/MS/MS (MRM) and yield little adsorption.

Researchers have used mass spectrometry imaging to uncover exactly how a human egg captures an incoming sperm to begin the fertilisation process, in a new study published this week in Science. The research identifies the sugar molecule that makes the outer coat of the egg “sticky”, which is vital for enabling the sperm and egg to bind together. Researchers across the world have been trying to understand what performs this task for over 30 years.

This Product Focus is on Mass Spectrometry, and a number of companies have provided information on their key products, their applications and features.

Applications of mass spectrometry in the clinical area have increased significantly in recent years and continue to expand. The complexity of analyses has also increased, with work being undertaken in clinical labs that would have been the reserve of research labs a few years ago.

The European Molecular Biology Organization (EMBO) and the Federation of European Biochemical Societies (FEBS) announce Carol V. Robinson, Professor of Chemistry at the University of Oxford, UK, as the winner of the 2011 FEBS/EMBO Women in Science Award. Professor Robinson has been recognised for her pioneering work in the development of mass spectrometry as a tool used for investigating the structure and dynamics of protein complexes.

The new TLC-MS interface from CAMAG is a versatile instrument which is capable of isolating unknown compounds from a TLC/HPTLC plate and introducing them into a mass spectrometer for substance identification or structure elucidation. It can be connected to any brand of LC-coupled mass spectrometer and is compatible with all common HPLC-MS systems. Features include rapid and convenient extraction directly into your MS, identification of unknown substances, confirmation of target compounds, offering semi-automatic performance, reproducible results and detectability similar to HPLC-MS, compatibility with most common TLC/HPTLC layers and enables extraction into vials for NMR or (ATR) FT-IR, static nanospray, direct inlet EI-MS and MALDI.

Premier Biosoft has introduced version 2.92 of its MS data tool, SimGlycan. This program now includes comprehensive support to perform multi-stage/sequential mass spectrometry data analysis which involves re-fragmentation of product ions. Multi-stage mass analysis provides structural information that is useful in structure elucidation of metabolites, glycopeptides and glycans. It aids in discrimination of glycans which have similar characteristic fragment ions at MS/MS level and resolves heterogeneity of carbohydrate distribution and branching patterns of complex glycans such as isobaric isomers.

Premier Biosoft has announced the release of its SimLipid. SimLipid analyses mass spectrometric data for characterising lipids, greatly advancing lipidome data analysis. It profiles lipids by matching the experimental MS spectra with its own comprehensive annotated database which consists of nine lipid classes and 1948 lipid species. It retrieves lipids that correspond with the observed m/z and user-specified filter criteria. Alongside the probable lipid structure, important information such as the lipid ID, abbreviation, systematic name, category, mass, chemical formula and other database links is also made available. Users can also look up the database using abbreviation, mass, chemical composition or lipid ID.

Metabolic profiling of tissue samples could transform the way surgeons make decisions in the operating theatre, say researchers at a new laboratory. Scientists at Imperial College London, in partnership with clinicians at Imperial College Healthcare NHS Trust, have installed a high resolution solid state nuclear magnetic resonance (NMR) spectrometer in St Mary’s Hospital. Researchers will use the machine to analyse intact tissue samples from patients taking part in studies, to investigate whether it can ultimately give surgeons detailed diagnostic information while their patients are under the knife.

Professor Peter Derrick, has been elected as a Fellow of the Royal Society of New Zealand. Fellowship is an honour given to top researchers in New Zealand for showing distinction in research or in the advancement of science, technology or the humanities. Peter Derrick moved to New Zealand from the University of Warwick, UK, about four years ago to head the Institute of Fundamental Sciences at Massey University.