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Orthogonal spectroscopic techniques for the early developability assessment of therapeutic protein candidates
Orthogonal spectroscopic techniques for the early developability assessment of therapeutic protein candidates” are described by Patrick Garidel, Anne Karow and Michaela Blech. Due to its cost and time implications, in the early development phase of drug discovery the use of othogonal techniques, based on different physical observables, is important for correct decision-making.
Matrix–assisted laser desorption ionisation tandem mass spectrometry imaging of small molecules from latent fingermarks
Robert Bradshaw and Simona Francese tell us about “Matrix–assisted laser desorption ionisation tandem mass spectrometry imaging of small molecules from latent fingermarks“. Especially when looking at small molecules in fingermarks, isobaric species can be a problem and this has the potential to affect the outcome of any court case if not handled appropriately. Tandem mass spectrometry can be used as an alternative to high-resolution MS and ion mobility.
“Membrane inlet mass spectrometry for in situ environmental monitoring” by Simon Maher, Fred Jjunju, Iain Young, Boris Brkic and Stephen Taylor looks at a technique that is 50 years old but is now being applied for field analysis. As well as a brief overview of the technique, they show how it can be used to monitor oil-in-water levels before discharge from oil termini.
The use of liquid chromatography tandem mass spectrometry for the investigation of suspected (pesticide) poisoning of vertebrate animals and beneficial insects
This article explains the challenges in pesticide residue analysis of samples associated with suspected poisoning incident investigations, including the wide range of specimens and pesticides that need to be considered.
In this article we learn of a new definition for “bath salts”, and how modern mass spectrometry instrumentation can provide rapid and quantitation of these “designer” drugs.
This article shows that pyrolysis techniques, in combination with spectroscopy, are helping our understanding of how the organic matter in our solar system came to be. Fascinatingly, they also show how secondary processing of meteorite materials seems to enhance the abilities of atmospheres to host life on planetary surfaces as well as providing the raw materials from which life could originate.
The use of isotope ratio mass spectrometry is on the rise, with more papers published and more labs with the facilities. The authors describe the main IRMS studies conducted on seeds and isotopes and outline the most important aspects of the use of seeds to study plant eco-geochemistry and plant material traceability.
There are many reasons for quantifying VOCs in air, from investigating pollution to diagnosis of diseases in humans. PTR-MS has many advantages for this, not least in speed and ability to provide an online analysis. It is a relatively young technique, but has a range of applications from botany and medicine through to industrial process monitoring, security screening, environmental analysis and food science.
“Mass spectrometry investigations of nanoparticles by tandem charge detection mass spectrometry” by Tristan Doussineau, Philippe Dugourd and Rodolphe Antoine describes how the limitation of conventional mass spectrometry for weighing macro-ions with masses higher than one megadalton can be overcome with the technique of charge detection mass spectrometry and how they have developed such an instrument for performing MS/MS. This has potential for exploring the “nano world”.
Scientists at the University of Warwick have developed a computation which simultaneously doubles the resolution, sensitivity and mass accuracy of Fourier Transform Mass Spectrometry (FT-MS) at no extra cost.
The Extrel MAX-HM series quadrupole mass spectrometers from Henniker Scientific are now available with extended mass range options to 16,000 amu. Each instrument features the quadrupole mass filter assembly, a precision machined 9.5 mm or 19 mm rod set with improved RF-only pre- and post-filter stages, stabilising rods and high-power generators that, in combination, deliver improved transmission, resolution and abundance sensitivity characteristics at high masses. They are all available as a fully UHV compatible bolt-on instrument or with application matched single or compound molecular beam inlet pressure reduction stages, addressing a wide range of atomic and molecular studies, including nano-cluster deposition, analysis of biomolecules, plasma polymerisation and SIMS/SNMS of polymeric materials. The range covers discreet upper mass limits of 500 amu, 1000 amu, 2000 amu, 4000 amu and 16,000 amu with a frequency specific and interchangeable RF generator that also allow a single instrument to operate over multiple mass ranges without the need for re-tuning.
Fully dedicated LC/MS and GC/MS benches which are compatible with all MS manufacturers. For easy access to the rear of the instruments, and for ease of movement to other instruments, the benches are all on casters. Space is saved as no service corridor is needed.
A mass spectrometry source using OpenSpot sample cards for the analysis of raw materials, formulations, reaction products and unknown materials without sample preparation. The closed region of the source minimises sample contamination and contains vapours of derivatising agents and dopants used for analysis of more complex samples.
An ion source to meet the increasing demands for sensitivity enhancements in environmental analysis, food testing and forensics. It has been designed with the same fittings as other Bruker Apollo II sources, allowing quick and easy exchange with conventional ESI and APCI and it is compatible with all recent Bruker mass spectrometers.
A compact mass spectrometer designed for the discovery research and process development synthetic organic chemistry market. Compact enough to operate in fume hoods and space-restricted laboratories, users have direct access to identify, monitor and confirm compounds as they are created in the reactor. Personal single quadrupole mass spectrometers allow for rapid compound confirmation in normal phase chromatography fractions.
A bundle of solution packages which consist of a mass spectrometer, software, training, validation services and a liquid chromatography system which includes the Eksigent ekspert ultra 100 and 100-XL systems, which are analytical flow rate systems.
A triple quadrupole mass spectrometry system for routine quantitation and screening, offering improved sensitivity and a more rugged design. It is also available with the option of QTRAP technology which increases full-scan sensitivity over triple quadrupoles by incorporating the Linear Accelerator.
Miniature mass spectrometer designed for use in the research laboratory. It is capable of rapid MS/MS detection of trace levels of volatile compounds in approximately five seconds. It uses a cylindrical ion trap and offers sensitivity to 1 ppt with the optional Precon-1000, non-cryogenic pre-concentrator which enhances sensitivity and is fast (<30 s). Mass range is 35–450 Da and resolution <0.5 Da FWHM.
A person-portable capillary gas chromatoraph-toroidal ion trap mass spectrometer with high-speed temperature programming and a miniature toroidal ion trap mass spectrometer with a nominal mass resolution over a mass range of 50 Da to 500 Da. It is totally self-contained, weighs less than 32 pounds with all accessories, is battery operated and has on-board helium GC carrier gas supply cartridge.