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This Product Focus is on Mass Spectrometry, and a number of companies have provided information on their key products, their applications and features.
Applications of mass spectrometry in the clinical area have increased significantly in recent years and continue to expand. The complexity of analyses has also increased, with work being undertaken in clinical labs that would have been the reserve of research labs a few years ago.
The European Molecular Biology Organization (EMBO) and the Federation of European Biochemical Societies (FEBS) announce Carol V. Robinson, Professor of Chemistry at the University of Oxford, UK, as the winner of the 2011 FEBS/EMBO Women in Science Award. Professor Robinson has been recognised for her pioneering work in the development of mass spectrometry as a tool used for investigating the structure and dynamics of protein complexes.
The new TLC-MS interface from CAMAG is a versatile instrument which is capable of isolating unknown compounds from a TLC/HPTLC plate and introducing them into a mass spectrometer for substance identification or structure elucidation. It can be connected to any brand of LC-coupled mass spectrometer and is compatible with all common HPLC-MS systems. Features include rapid and convenient extraction directly into your MS, identification of unknown substances, confirmation of target compounds, offering semi-automatic performance, reproducible results and detectability similar to HPLC-MS, compatibility with most common TLC/HPTLC layers and enables extraction into vials for NMR or (ATR) FT-IR, static nanospray, direct inlet EI-MS and MALDI.
Premier Biosoft has introduced version 2.92 of its MS data tool, SimGlycan. This program now includes comprehensive support to perform multi-stage/sequential mass spectrometry data analysis which involves re-fragmentation of product ions. Multi-stage mass analysis provides structural information that is useful in structure elucidation of metabolites, glycopeptides and glycans. It aids in discrimination of glycans which have similar characteristic fragment ions at MS/MS level and resolves heterogeneity of carbohydrate distribution and branching patterns of complex glycans such as isobaric isomers.
Premier Biosoft has announced the release of its SimLipid. SimLipid analyses mass spectrometric data for characterising lipids, greatly advancing lipidome data analysis. It profiles lipids by matching the experimental MS spectra with its own comprehensive annotated database which consists of nine lipid classes and 1948 lipid species. It retrieves lipids that correspond with the observed m/z and user-specified filter criteria. Alongside the probable lipid structure, important information such as the lipid ID, abbreviation, systematic name, category, mass, chemical formula and other database links is also made available. Users can also look up the database using abbreviation, mass, chemical composition or lipid ID.
Metabolic profiling of tissue samples could transform the way surgeons make decisions in the operating theatre, say researchers at a new laboratory. Scientists at Imperial College London, in partnership with clinicians at Imperial College Healthcare NHS Trust, have installed a high resolution solid state nuclear magnetic resonance (NMR) spectrometer in St Mary’s Hospital. Researchers will use the machine to analyse intact tissue samples from patients taking part in studies, to investigate whether it can ultimately give surgeons detailed diagnostic information while their patients are under the knife.
Professor Peter Derrick, has been elected as a Fellow of the Royal Society of New Zealand. Fellowship is an honour given to top researchers in New Zealand for showing distinction in research or in the advancement of science, technology or the humanities. Peter Derrick moved to New Zealand from the University of Warwick, UK, about four years ago to head the Institute of Fundamental Sciences at Massey University.
Thermo Fisher Scientific has published an application note entitled Confirmation and Quantitation of an Expanded Panel of Sympathomimetric Amines in Urine Using Single Quadrupole GC/MS which describes a method for the confirmation of amphetamines in urine in accordance with recently updated US Substance Abuse and Mental Health Service Administration Mandatory Guidelines for Federal Workplace Drug Testing Programmes.
Thermo Fisher Scientific
Thermo Fisher Scientific has developed a new method for sensitive, accurate and reproducible quantitation of low levels of PFCs in human breast milk. Using selected reaction monitoring and highly-selective reaction monitoring on a UHPLC/MS platform enables reliable and robust detection of PFCs at ppt concentrations. The new method is detailed in an application note entitled Sensitive and Accurate Quantitation of Perfluorinated Compounds in Human Breast Milk using Selected Reaction Monitoring Assays by LC/MS/MS. Using the integrated UHPLC/MS platform, separation of the six PFC analytes in a spiked human breast milk matrix was achieved within nine minutes. As the majority of interferences from matrices elute early at void volume, elution of the first compound at 3.64 minutes ensured a robust quantitation method.
Thermo Fisher Scientific
Almsco International has announced a solution for the characterisation of crude oils over traditional GC/MS techniques. The BenchTOF-dx uses two-dimensional GC combined with time-of-flight spectrometry and is capable of producing classic EI ionisation spectra. The company has produced a poster which details this application. The BenchTOF-dx extends the range over which ToF mass detectors for GC are able to record molecular ions making it ideal for analysing compounds such as crude oil. Compound spectra are produced in the classic format used in commercial spectral libraries, enabling the use of proprietrary petrochemical spectral libraries.
Hiden Analytical have introduced a family of quadrupole mass spectrometers designed specifically for UHV/XHV performance, evolved from their 3F series concept and incorporating their triple-stage mass filter technology for mass separation, ion transmission efficiency and contamination resistance. Pulse ion counting detection is common throughout this series, with a choice of positive-ion-only or combined positive and negative ion detection. Quadrupole mean energy scanning is featured for systems configured for analysis of externally generated ions. All systems feature the Windows MASsoft Pro multi-mode control program with multi-parameter scanning for optimisation of operating parameters for each individual mass channel. A choice of ionisation sources enables system optimisation for varied applications including molecular beam, laser ablation, thermal desorption and general neutral studies. All ion source parameters are software-controlled with modes for ion attachment, “soft” ionisation and appearance potential measurement.
Thermo Fisher Scientific has announced Mass Frontier 7.0, the newest release of its small molecule structural elucidation software. The software simplifies the management, evaluation and interpretation of mass spectral data and can be used for metabolism, metabolomics, forensics, natural products, impurities and degradants research. Its features improve ease-of-use, increase throughput of compounds analysed, reduces potential for false results and offer more confident structural elucidation.
Almsco has launched its TargetView software package, which has been designed to automate and improve the detection and measurement of multiple target chemicals in complex GC/MS datasets, benefitting users in the fields of environmental monitoring, food/flavour/fragrance profiling, forensic science and testing chemical emmisions from consumer goods. The software package compares deconvoluted mass spectral data against EI mass spectra in existing libraries, can automatically detect many target compounds in one run and immediately generates a simple customiseable report which includes retention times, quantification ions, peak area values and match coefficients as required.
Thermo Fisher Scientific has developed a suite of five complementary software solutions and enhancements designed to effect progress in qualitative and quantitative proteomics. Working in concert with the company's mass spectrometers, the software solutions provide researchers with fast, simple workflows for many proteomics challenges. ProteinCenter software is a web-based tool designed for faster more confident integration, interpretation and sharing of proteomics data. Protein Discoverer software is a comprehensive platform for the analysis of qualitative and quantitative proteomics data. SIEVE software is an automated solution for the label-free, semi-quantitative differential expression analysis of proteins, peptides and metabolites. Pinpoint software simplifies the transition from early-stage biomarker discovery to larger-scale, quantitative verification of putative biomarkers. ProSightPC software harnesses the high precursor and fragment mass accuracy of the company's mass spectrometers to provide high-confidence identification and characterisation of peptides and intact proteins.
Thermo Fisher Scientific
Thermo Fisher Scientific has announced the availability of its MetQuest software solution which enables laboratories to take full advantage of their Orbitrap mass spectrometry high-resolution, accurate-mass, full-scan data to perform quantitative metabolic stability studies and identify putative metabolites in a single injection. The software enables researchers to routinely perform quantitative and qualitative analyses in the same run. The processing methods in the software have been specifically developed to automatically process full-scan high-resolution data for compound identification from even the most complex biological matrices without the need for pre-defined mass-to-charge values. The software does not require MS/MS method development and optimisation, so acquisition methods are simple to set up and a single method can be used for multiple compounds and the automated generation of metabolic stability plots from the processed data saves time.
Thermo Fisher Scientific
The new MAXIM SIMS/SNMS workstation from Hiden Analytical combines high-sensitivity surface measurement by both secondary ion and sputtered neutral mass spectrometry. The system is suited to both static and dynamic measurement and is fully UHV compliant with a choice of oxygen, argon and caesium ion sources for broad-beam applications and for fine-focus operation to 20 µm spot size. The workstation is configured to accept diverse sample types and, together with the in-built elemental surface imaging program, provides for quantitative analysis of surface composition and/or depth profile features.
Hiden Analytical Ltd