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Tag: Microscopy Ordering
Toptica has appointed Howard Potter as their direct representative for UK and Ireland. www.toptica.com

Recently, medical researchers have begun to investigate the ways in which IR instruments can be applied to diagnosing disease states in tissue samples. An IR microscopy imaging system can obtain high-quality spectra from small sample areas and the use of an automated microscope stage and control software speeds the gathering of spectra in a precise 2-D grid. As a result, researchers can examine a spatial and spectral image of a tissue sample full of biochemical information that reveals minute chemical changes in both cell structure and composition. Figure 1 compares a visible and IR image of rabbit aorta tissue to highlight the wealth of information obtained through IR imaging. Researchers are currently using FT-IR systems to investigate earlier detection of cardiovascular disease, the staging and detection of various cancers, and the characterization of bone diseases. Cancer researchers in particular are using IR imaging and linear discriminant analysis to reduce dependence on human observation of histological patterns. Prostate cancer, for instance, exhibits measurable ratios of glycogen and phosphate that vary in normal, benign and malignant tissues.

PerkinElmer Issue: 16/03 RSN: 131

A new application note from SensIR Europe describes and illustrates how infrared microspectroscopy aids rapid identification and morphological evaluation of solid pharmaceutical excipients. It illustrates how the Illuminator microspectrometry system may be used to collect visual and spectroscopic information on different solid excipients within a formulation. As an accessory to a standard infinity-corrected optical microscope, the Illuminator provides a valuable molecular spectroscopic analysis capability. Identification of the excipients is achieved automatically through the QualID software by comparing the collected spectra to a library of reference spectra. The note illustrates how this information can then be combined with the morphological information in the digital images to fully characterise particles in blended pharmaceutical formulations.

Smiths Detection Issue: 15/04 RSN: 133

A new application note from SensIR Europe describes how infrared microspectroscopy aids rapid identification and morphological evaluation of solid pharmaceutical excipients. It illustrates how the Illuminator microspectrometer system may be used to collect visual and spectroscopic information on different solid excipients within a formulation and. as an accessory to a standard infinity-corrected optical microscope, the Illuminator provides molecular spectroscopic analysis capabilities. Identification of the excipients is achieved automatically through the QualID software by comparing the collected spectra to a library of reference spectra. The note shows how this information can then be combined with the morphological information in the digital images to fully characterise particles in blended pharmaceutical formulations.

Smiths Detection Issue: 15/03 RSN: 131