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Tag: Process Ordering

With the impact of initiatives like Process Analytical Technology (PAT) in the pharmaceutical industry, the ability to transfer methods without re-running calibration standards is of paramount importance in NIR spectroscopy. NIR analytical methods, which are typically developed in research or QC labs, can be readily migrated out to multiple production sites. If, however, the methods do not transfer, i.e. give the same predicted numbers from one spectrometer to another, time-consuming re-collection of standards is required for each instrument where the method is implemented. Re- scanning of all standards in a method is so time consuming that it quickly becomes prohibitive when there are many methods involved, greatly reducing the value of NIR as a QC tool. The present study examines and addresses method transfer issues using a real method transfer case. In the study, a food method and calibration built on a dispersive spectrometer is transferred with minimal effort to a FT spectrometer manufactured by Thermo Electron Corporation.

Thermo Fisher Scientific Issue: 16/04 RSN: 130

The use of an on-line UV/vis diode array spectrophotometer at a cobalt recovery plant to provide continuous monitoring of a number of process streams for low levels of Co2+, Ni2+, Cu2+ and Fe2+ is described. The diode array spectrophotometer was used to measure the complete absorbance spectrum of the sample from 190 to 1100 nm with 1 nm resolution. The cobalt, nickel, copper and iron ions all show unique absorbance spectra. Absorbance values at certain wavelengths were correlated via a multi-component calibration method to the metal ions concentrations. Calibration of the system for quantitative determination is described.

Applied Analytics Inc Issue: 10/03 RSN: 177
Tags: UVvis Process